{"id":2739,"date":"2007-02-05T12:19:13","date_gmt":"2007-02-05T11:19:13","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=2739"},"modified":"2013-09-20T18:10:13","modified_gmt":"2013-09-20T18:10:13","slug":"increased-prevalence-of-cardiovascular-disease-among-hiv-infected-individuals-coinfected-with-hepatitis-c","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/2739","title":{"rendered":"Increased prevalence of cardiovascular disease among HIV-positive individuals coinfected with hepatitis C"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>Matthew Frieberg and colleagues from University of Pittsburgh published results in the 11 January issue of AIDS, from a cross sectional analysis looking at the association between hepatitis C and prevalent cardiovascular disease (CVD) among HIV-positive patients.<\/strong><\/p>\n<p>Patients were enrolled between August 2001 to July 2003 from the HIV-Longitudinal Interrelationships of Viruses and Ethanol (HIV-LIVE) cohort. This is a prospective cohort of HIV-positive\u00a0individuals with current or past alcohol problems.<\/p>\n<p>They analysed health questionnaire and laboratory data from 400 HIV-positive\u00a0individuals (50% co-infected with hepatitis C) from the HIV-Longitudinal Interrelationships of Viruses and Ethanol (HIV-LIVE) cohort. Five participants were later excluded because of missing hepatitis C RNA data (n = 4) or a history of CVD data (n = 1).<\/p>\n<p>CVD was defined as a \u0091yes\u0092 response to one of the three following questions: \u0091Has a doctor ever told you that you had\u0085 i) peripheral vascular disease (hardening of the arteries in your neck or legs, atherosclerosis); ii) a stroke, cerebrovascular accident, blood clot or bleeding in the brain, or transient ischemic attack; or iii) a heart attack (myocardial infarction)?\u0092<\/p>\n<p>Compared with the HIV-monoinfected patients, those with co-infection were older (43.9 versus 40.9 years), had a higher prevalence of ever having had diabetes (10.1 versus 4.1%), cirrhosis (10.6 versus 2.5%), myocardial infarctions (6.5 versus 0.5%), and CVD (11.1 versus 2.5%), and a lower prevalence of hypercholesterolemia (19.7 versus 33.0%); p&lt;0.05 for all.<\/p>\n<p>After adjusting for age, the OR, estimated by logistic regression, for the prevalence of CVD was significantly higher among those with hepatitis C co-infection (adjusted OR 4.65, 95%CI 1.70-12.71), and was maintained when adjusting other sociodemographic characteristics, including substance use, and cardiovascular risk factors in separate regression models. Analyses excluding participants with diabetes yielded similar results.<\/p>\n<p>Although the small number of self-reported cardiovascular events in the monoinfected group limited the ability to adjust for confounders in the multivariable models, the investigators concluded that their data suggest that hepatitis C infection may be associated with an increased risk of CVD among those co-infected with HIV. They cautioned that as all the participants in this cohort had alcohol problems, the findings may not be generalisable to the HIV-positive\u00a0population without alcohol problems.<\/p>\n<p class=\"ref\">Reference:<\/p>\n<p class=\"ref\">Freiberg MS, Cheng DM, Kraemer KL The association between hepatitis C infection and prevalent cardiovascular disease among HIV-infected individuals. AIDS: Volume 21(2) 11 January 2007 p 193-197.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Matthew Frieberg and colleagues from University of Pittsburgh published results in the 11 January issue of AIDS, from a cross sectional analysis looking at the association between hepatitis C and prevalent cardiovascular disease (CVD) among HIV-positive &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-2739","post","type-post","status-publish","format-standard","hentry","category-hepatitis-coinfection"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/2739","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=2739"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/2739\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=2739"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=2739"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=2739"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}