{"id":27438,"date":"2014-10-01T12:09:40","date_gmt":"2014-10-01T12:09:40","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=27438"},"modified":"2014-10-06T13:15:24","modified_gmt":"2014-10-06T13:15:24","slug":"kidney-signal-trouble-worsens-over-5-years-in-japanese-on-tenofovir","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/27438","title":{"rendered":"Kidney signal trouble worsens over 5 years in Japanese on tenofovir"},"content":{"rendered":"

Mark Mascolini, IAS newsletter<\/strong><\/p>\n

Estimated glomerular filtration rate (eGFR), a signal of kidney function, declined steadily over 5 years in HIV positive Japanese taking tenofovir (TDF) compared with those taking abacavir. The TDF group did worse than the abacavir group by three eGFR measures.\u2028\u2028<\/strong><\/p>\n

The risk TDF poses to kidney function is well appreciated. But the long-term renal impact of TDF in people who continue taking this antiretroviral is not well understood. Typically, providers switch patients from TDF to another drug if their kidney function worsens.<\/p>\n

To assess the long-term effects of TDF on kidney function in HIV-positive people, especially those with low body weight, Japanese researchers conducted this 5-year study of 422 antiretroviral-naive people who started a TDF regimen and 370 who started an abacavir regimen. All patients received care at a single center in Tokyo. People with lower weight are more vulnerable to TDF kidney toxicity.<\/p>\n

The research team used logistic regression analysis to assess three renal endpoints: (1) decline in eGFR greater than 10 mL\/min relative to the baseline measure, (2) more than 25% decline in eGFR, and (3) eGFR lower than 60 mL\/min in two measures at least 3 months apart.<\/p>\n

The study group had a median weight of 63 kg. Taking TDF rather than abacavir at least doubled chances of reaching all three endpoints, at the following adjusted odds ratios (aOR) and 95% confidence intervals (CI):<\/p>\n