{"id":2837,"date":"2006-12-06T22:43:58","date_gmt":"2006-12-06T21:43:58","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=2837"},"modified":"2019-01-10T16:06:31","modified_gmt":"2019-01-10T16:06:31","slug":"us-perinatal-guidelines-updated","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/2837","title":{"rendered":"US perinatal guidelines updated (2006)"},"content":{"rendered":"<p><strong>On October 12, the Public Health Service Task Force updated its Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States.<\/strong><\/p>\n<p>Changes in this edition include:<\/p>\n<p><strong>Postpartum haemorrhage, antiretroviral drugs, and methergine use. <\/strong><\/p>\n<p>\u0093Methergine should not be co-administered with drugs that are potent CYP3A4 enzyme inhibitors, including protease inhibitors and the NNRTIs efavirenz and delavirdine&#8230;.\u0094<\/p>\n<p><strong>An update on preconceptual counseling and care for HIV-1-infected women of childbearing age. <\/strong><\/p>\n<p>It is recommended that all women of child-bearing age are offered the opportunity to receive preconception counseling and care as a component of routine primary medical care.<\/p>\n<p><strong>Lopinavir\/r (Kaletra) was added as a first-line preferred PI in HIV+ women who are pregnant; prior to this update nelfinavir (Viracept) was the only preferred PI. <\/strong><\/p>\n<p>There is an <strong>update on abacavir<\/strong>; in Table 3, \u0093pharmacokinetics are not significantly altered in pregnancy; no change in dose is indicated\u0094. The Guidelines are updated with information on the use of <strong>Darunavir (TMC114)<\/strong>. In addition, there is an update on Kaletra: in Table 3, \u0093pharmacokinetic studies of standard dose of lopinavir\/ritonavir capsules a (3 capsules twice daily) during 3rd trimester indicated levels were significantly lower than during postpartum period and in non-pregnant adults; an increased dose of 4 capsules of lopinavir\/ritonavir twice daily starting in the 3rd trimester resulted in adequate lopinavir exposure; by 2 weeks postpartum, standard dosing was again appropriate. Pharmacokinetic studies of the new lopinavir\/ritonavir tablet formulation are underway, but data are not yet available.\u0094 And there is additional information in the Guidelines.<\/p>\n<p>Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women:<br \/>\n<a href=\"http:\/\/aidsinfo.nih.gov\/ContentFiles\/PerinatalGL.pdf\" rel=\"noopener\">http:\/\/aidsinfo.nih.gov\/ContentFiles\/PerinatalGL.pdf <\/a> 1.6Mb PDF<\/p>\n","protected":false},"excerpt":{"rendered":"<p>On October 12, the Public Health Service Task Force updated its Recommendations for Use of Antiretroviral Drugs in Pregnant HIV-1-Infected Women for Maternal Health and Interventions to Reduce Perinatal HIV-1 Transmission in the United States. Changes in this edition include: &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[35,23],"tags":[],"class_list":["post-2837","post","type-post","status-publish","format-standard","hentry","category-pmtct-and-maternal-health","category-guidelines"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/2837","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=2837"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/2837\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=2837"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=2837"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=2837"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}