{"id":292,"date":"2008-12-26T10:09:18","date_gmt":"2008-12-26T09:09:18","guid":{"rendered":"http:\/\/localhost\/new\/htb\/?p=292"},"modified":"2013-08-23T12:57:20","modified_gmt":"2013-08-23T12:57:20","slug":"hiv-reinfection-reported-in-10-of-couples-in-zambian-study","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/292","title":{"rendered":"HIV reinfection reported in 10% of couples in Zambian study"},"content":{"rendered":"

Simon Collins, HIV i-Base<\/strong><\/p>\n

A poster from C Kraft and colleagues from the Zambia Emory HIV Research Project reported on the incidence of HIV subtype C reinfection in heterosexual couples infected with genotypically different viruses.<\/strong><\/p>\n

The study aimed to see whether reinfection could be detected, together with the frequency, and any virologic consequences.<\/p>\n

Seventeen unlinked couples were screened with a gp41-based heteroduplex mobility assay for reinfection and the results were confirmed by phylogenetic analysis of single genome amplified env genes.<\/p>\n

Three cases of reinfection were confirmed, only two of which occurred during early infection. In one case a newly infected partner was reinfected by their chronically infected spouse, and, in the second, reinfection of the seroconverting partner resulted from a second non-spousal transmission. In the third case, reinfection in a chronically infected partner occurred during acute infection of his partner’s unlinked infection.<\/p>\n

In two cases, reinfection was accompanied by a 10-fold increase in viral load. Phylogenetic analyses were consistent with rapid recombination between the reinfecting strains in each individual.<\/p>\n

The authors concluded “in this retrospective study of a limited number of HIV-1 infected cohabiting couples, superinfection appears to be a frequent event (3\/34).<\/p>\n

Comment<\/h3>\n

Similar rates of reinfection have been reported in several at least one other heterosexual study, although rates in MSM are still poorly studied.<\/strong><\/p>\n

It may be important that the case reinfection during chronic infection was from a partner in acute infection when vireamia is highest.<\/strong><\/p>\n

Reference:<\/p>\n

Kraft CS et al. HIV-1 superinfection in cohabiting Zambian heterosexual couples. 48th ICAAC, 25-28 October 2008. Washington. Abstract H-4049.<\/p>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base A poster from C Kraft and colleagues from the Zambia Emory HIV Research Project reported on the incidence of HIV subtype C reinfection in heterosexual couples infected with genotypically different viruses. The study aimed to see …<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,10],"tags":[102],"class_list":["post-292","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-transmission-and-prevention","tag-icaac-48th-2008"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=292"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/292\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}