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Simon Collins, HIV i-Base<\/strong><\/p>\n Starting ART in primary compared to chronic HIV infection had a significantly higher chance of getting a CD4:CD8 ratio >1.0 in a retrospective study in which individuals were their own controls.<\/strong><\/p>\n This was a retrospective analysis by Alexander Pasternak from University of Amsterdam and colleagues of 48 people who started a temporary period of ART in primary infection (PHI) – for either 24 or 60 weeks – and who after a median time of 2.4 years off-ART, subsequently restarted treatment again during chronic HIV infection (CHI).<\/p>\n As would be expected, the median CD4 count was higher at baseline for the PHI compared to CHI periods: 505 (IQR: 303 to 713) vs 310 (245 to 418) cells\/mm3 respectively (p< 0.0001).<\/p>\n However, there was no difference in the dynamics of CD4 recovery between the PHI and CHI follow-up periods with median CD4 increases of 210 cells\/mm3 at week-60 for both groups (although the PHI response reached higher absolute CD4 levels).<\/p>\n Although there were no significant differences between the CD4:CD8 ratio in the PHI vs CHI groups at baseline (0.48 (0.25-0.80) compared to 0.36 (0.25-0.41), respectively; p>0.05), there were significantly different increases in the CD4:CD8 ratio.<\/p>\n By week-12 this ratio increased to 0.95 (0.74 to 1.29) compared to 0.52 (0.41 to 0.74) in the PHI vs CHI periods respectively (p< 0.0001). The differences were sustained to week-48 with 59% compared to 29% of participants achieving a CD4:CD8 ratio > 1.0 (p=0.0049) in the PHI vs CHI periods respectively.<\/p>\n Reference:<\/p>\n Pasternak A et al. Faster restoration of CD4:CD8 ratio during the first 12 weeks of ART initiated at early HIV infection compared with ART initiated at chronic infection in the same patients. AIDS2016. Durban, South Africa. 18-22 July 2016. Poster abstract THPEB033. Simon Collins, HIV i-Base Starting ART in primary compared to chronic HIV infection had a significantly higher chance of getting a CD4:CD8 ratio >1.0 in a retrospective study in which individuals were their own controls. This was a retrospective analysis …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,41],"tags":[224],"class_list":["post-30407","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-treatment-strategies","tag-aids-21st-2016-durban"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/30407","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=30407"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/30407\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=30407"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=30407"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=30407"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\nhttp:\/\/programme.aids2016.org\/Abstract\/Abstract\/2641<\/a>\u00a0(Abstract)
\nhttp:\/\/programme.aids2016.org\/PAGMaterial\/eposters\/0_2641.pdf<\/a>\u00a0(Poster PDF)<\/p>\n","protected":false},"excerpt":{"rendered":"