{"id":3057,"date":"2006-09-09T20:37:00","date_gmt":"2006-09-09T19:37:00","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3057"},"modified":"2013-12-06T17:06:04","modified_gmt":"2013-12-06T17:06:04","slug":"prognostic-index-for-risk-of-progression-of-kaposis-sarcoma","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3057","title":{"rendered":"Prognostic index for risk of progression of Kaposi\u0092s Sarcoma"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>Mark Bower and colleagues from the Chelsea and Westminster Hospital London, presented a prognostic score for patients diagnosed with Kaposi\u0092s Sarcoma (KS), derived from analysing covariates predictive of overall survival in a cohort of 326 HIV+ patients who developed KS since 1996.<\/strong><\/p>\n<p>The score in these patients, ranged from 0 to 15 and was calculated starting at the number 10. It incorporated:<\/p>\n<ul>\n<li>S stage &#8211; other ADI: +3 (any other HIV-related illness)<\/li>\n<li>age: +2 (if &gt;50 years old at diagnosis)<\/li>\n<li>KS as first ADI: -2 (if KS is the ADI), and<\/li>\n<li>CD4 cell count: -1 (per 100 cells\/mm<sup>3<\/sup> at diagnosis)<\/li>\n<\/ul>\n<p>Individuals with a prognostic score of 0, 5, 10 and 15, had 1 year survivals of 99.4%, 96.7%, 83.4% and 37.8% and 5 year survivals of 98.4%, 91.8%, 63.1% and 8.4% respectively. Increasing the prognostic score by 1 increased the risk of death by 40% (HR 1.4, 95% CI 1.28-1.53, bootstrapped HR 1.39, 95% CI 1.25-1.51) and the index has a concordance of 76.8% (95% CI 71.7-82.3%). The prognostic index, validated internally using a bootstrap procedure with resampled data, applied to individuals on and off HAART at KS diagnosis.<\/p>\n<p>The study concluded that this score can be used to guide therapeutic options.<\/p>\n<p class=\"ref\">Reference:<\/p>\n<p class=\"ref\">Bower M, Sanitt A, Mazhar D et al. A prognostic index for AIDS-associated Kaposi Sarcoma in the era of highly active antiretroviral therapy. Poster abstract TUPE0046.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Mark Bower and colleagues from the Chelsea and Westminster Hospital London, presented a prognostic score for patients diagnosed with Kaposi\u0092s Sarcoma (KS), derived from analysing covariates predictive of overall survival in a cohort of 326 HIV+ &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,31],"tags":[151],"class_list":["post-3057","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-opportunistic-infections-coinfections-and-complications","tag-aids-16th-toronto-2006"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3057","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3057"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3057\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3057"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3057"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3057"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}