{"id":30693,"date":"2016-10-01T09:19:36","date_gmt":"2016-10-01T09:19:36","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=30693"},"modified":"2016-10-03T19:00:54","modified_gmt":"2016-10-03T19:00:54","slug":"higher-rates-of-eye-complications-in-hiv-positive-people-on-art","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/30693","title":{"rendered":"Higher rates of eye complications in HIV positive people on ART"},"content":{"rendered":"

\"AIDS<\/a>Simon Collins, HIV i-Base<\/strong><\/p>\n

A prospective South African study in 342 people looked at rates of optical complications and associations with HIV status and time on ART.<\/strong><\/p>\n

This group included: HIV-negative (n=105), HIV positive not on ART (n=16), HIV positive on ART for <12 months (short-term) (n=56) and HIV positive on ART for >36 months (long-term; n=165). All participants received full ophthalmic examination including fundoscopy.<\/p>\n

Ocular disease was diagnosed in 218\/342 people (64%). with HIV associated with a 3-fold higher rate or any ocular condition on (OR=3.1; 1.7-7.7; p< 0.001) and 2-fold risk of having more eye complaints (OR=1.9; 95% CI: 1.1-3.2, p=0.020), compared to HIV negative participants.<\/p>\n

Conditions affecting the external eye, anterior chamber or posterior chamber, but not the neuro-ophthalmic segment, were significantly more common among HIV positive individuals (Table 1).<\/p>\n

Within the HIV positive group, after adjusting for age, longer ART use was associated with higher rates of clinical cataract (57% vs. 38%; aOR 2.2, p=0.01) and HIV retinopathy (30% vs. 11%; age-aOR 3.4, p<0.05).<\/p>\n\n\n\n\n\n\n\n
Table 1: Eye complications in HIV positive vs negative people<\/caption>\n
<\/td>\nHIV+ on ART<\/th>\nHIV-neg<\/th>\nOR (95%CI)<\/th>\np-value<\/th>\n<\/tr>\n
External Eye<\/th>\n40 (17%)<\/td>\n7 (7%)<\/td>\n2.8 (1.6 to 6.6)<\/td>\n0.015<\/td>\n<\/tr>\n
Anterior Chamber<\/th>\n79 (33%)<\/td>\n18 (67%)<\/td>\n6.5 (0.8 to 5.0)<\/td>\n0.07<\/td>\n<\/tr>\n
Posterior Chamber<\/th>\n58 (24%)<\/td>\n10 (10%)<\/td>\n3.1 (1.5 to 6.4)<\/td>\n0.001<\/td>\n<\/tr>\n
Neuro-ophthalmic<\/th>\n8 (8%)<\/td>\n25 (11%)<\/td>\nns<\/td>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Reference:<\/p>\n

Peters R et al. Ocular conditions are more common among HIV-infected individuals using ART for an extended period of time. AIDS 2016, Durban. Poster abstract WEPE108
\nhttp:\/\/programme.aids2016.org\/Abstract\/Abstract\/2476<\/a>\u00a0(Abstract)
\nhttp:\/\/programme.aids2016.org\/PAGMaterial\/eposters\/0_2476.pdf <\/a>(PDF poster)<\/p>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base A prospective South African study in 342 people looked at rates of optical complications and associations with HIV status and time on ART. This group included: HIV-negative (n=105), HIV positive not on ART (n=16), HIV positive …<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3,31],"tags":[224],"class_list":["post-30693","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","category-opportunistic-infections-coinfections-and-complications","tag-aids-21st-2016-durban"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/30693","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=30693"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/30693\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=30693"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=30693"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=30693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}