{"id":3183,"date":"2006-06-10T22:43:19","date_gmt":"2006-06-10T21:43:19","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3183"},"modified":"2013-12-06T18:10:08","modified_gmt":"2013-12-06T18:10:08","slug":"saquinavirr-1000100mg-levels-reduced-when-taken-fasted-and-should-be-taken-with-food","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3183","title":{"rendered":"Saquinavir\/r (1000\/100mg) levels reduced when taken fasted and should be taken with food"},"content":{"rendered":"

Simon Collins, HIV i-Base<\/strong><\/p>\n

Marta Boffito and colleagues from the Chelsea and Westminster Hospital, compared absorption of saquinavir 500mg (dosed at 1000mg SQV with 100mg RTV, twice daily) when taken with a high calorie fat-containing meal (~ 1070kcal; 46-66g of fat), to when taken under fasted conditions.<\/strong> [1] An interim analysis of 10\/22 patients who completed this cross-over study, where three consecutive doses were taken in either fed\/fasted or fasted\/fed state, separated by one week.<\/strong><\/p>\n

Administration of SQV\/r under fasted conditions resulted in an approximate 70% decrease in SQV<\/p>\n

PK parameters, and are detailed in Table 1. There was no significant change in ritonavir PK. The researchers concluded that saquinavir\/r should be taken with food in order to ensure maximum therapeutic exposure.<\/p>\n

Table 1: Saquinavir levels (fed and fasted)<\/strong><\/p>\n\n\n\n\n\n\n
<\/td>\nFed<\/strong><\/td>\nFasted<\/strong><\/td>\n<\/tr>\n
AUC ng.h\/mL<\/strong><\/td>\n38,927<\/td>\n11,478<\/td>\n<\/tr>\n
Cmax ng\/mL<\/strong><\/td>\n6,399<\/td>\n1,587<\/td>\n<\/tr>\n
Ctrough ng\/mL<\/strong><\/td>\n1,294<\/td>\n373<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n

Reference:<\/p>\n

Boffito M et al. Effect of a fat-containing meal on the pharmacokinetic (PK) profile of saquinavir 500mg tablet\/ritonavir (SQV\/r) 1000\/100 mg BID in HIV-infected individuals. 7th International Workshop on Clinical Pharmacology of HIV Therapy, 20-22 April 2006, Lisbon. Abstract 66.<\/p>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base Marta Boffito and colleagues from the Chelsea and Westminster Hospital, compared absorption of saquinavir 500mg (dosed at 1000mg SQV with 100mg RTV, twice daily) when taken with a high calorie fat-containing meal (~ 1070kcal; 46-66g of …<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,3],"tags":[143],"class_list":["post-3183","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-antiretrovirals","tag-pk-workshop-2006"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3183","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3183"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3183\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3183"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3183"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3183"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}