{"id":332,"date":"2008-12-27T00:56:50","date_gmt":"2008-12-26T23:56:50","guid":{"rendered":"http:\/\/localhost\/new\/htb\/?p=332"},"modified":"2013-08-23T12:46:55","modified_gmt":"2013-08-23T12:46:55","slug":"haart-suppresses-genital-tract-hiv-shedding-in-hivhsv-co-infected-women","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/332","title":{"rendered":"HAART suppresses genital tract HIV shedding in HIV\/HSV co-infected women"},"content":{"rendered":"<p><strong>Polly Clayden, HIV i-Base<\/strong><\/p>\n<p><strong>There is limited data describing the effect of chronic HSV suppression on genital tract (GT) HIV among women on HAART.<\/strong><\/p>\n<p>Preliminary data was shown from a group of 34 women with HIV-1 \/ HSV-2 co-infection. The women in this study were receiving HAART with plasma viral load &lt;75 copies\/mL stable for at least 3 months prior to entry, and were randomly assigned to receive acyclovir 800 mg twice daily (n=22) or no acyclovir (n=12). Paired plasma and GT viral loads and GT HSV DNA values were taken every 4 weeks.<\/p>\n<p>The mean baseline age of the women was 46 years and CD4 count 504 cells\/mm3. 39% of women were white, 36% black and 18% Latino. None had positive tests for gonorrhoea, chlamydia, syphilis or HSV shedding and one had a positive trichomonas test at baseline.<\/p>\n<p>Over the first 3 study visits (n= 97), 5 women experienced an episode of asymptomatic HSV shedding, 1\/22 (4.5%) in the acyclovir arm and 4\/12 (33.3%) in the control arm (p=0.04, OR=0.10, CI 0.0-1.2). These were not associated with GT HIV shedding. 5 women had episodes of GT HIV shedding during 7 follow-up visits (4250-850,000 copies\/mL); 3\/22 in the acyclovir arm and 2\/12 in the control arm (p=1.0, OR=0.8, CI 0.08 to 11.0).<\/p>\n<p>The investigators found predictors of GT HIV were detectable plasma viral load (OR 12.8, CI 2.5 -66.4) and baseline GT shedding (OR 5.98, CI 0.96 -37.1). Risk factors for HSV shedding in the acyclovir arm and GT HIV shedding in both arms were poor adherence to acyclovir and HAART respectively.<\/p>\n<p>They concluded that the results of this small study reinforce the importance of HAART in decreasing HIV sexual transmission.<\/p>\n<p>Reference:<\/p>\n<p>Nijhawan A, Delong A, Chapman A et al. Highly Active Antiretroviral Therapy suppresses genital tract HIV shedding with or without chronic HSV suppression among HIV-1\/HSV-2 co-infected women. 48th ICAAC, 25-28 October 2008. Washington. Abstract H-2328.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Polly Clayden, HIV i-Base There is limited data describing the effect of chronic HSV suppression on genital tract (GT) HIV among women on HAART. Preliminary data was shown from a group of 34 women with HIV-1 \/ HSV-2 co-infection. The &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,44],"tags":[102],"class_list":["post-332","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-womens-health","tag-icaac-48th-2008"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/332","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=332"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/332\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=332"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=332"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=332"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}