{"id":3423,"date":"2006-04-13T21:24:55","date_gmt":"2006-04-13T20:24:55","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3423"},"modified":"2013-12-06T19:42:04","modified_gmt":"2013-12-06T19:42:04","slug":"association-of-hiv-replication-capacity-with-mother-to-child-transmission","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3423","title":{"rendered":"Association of HIV replication capacity with mother to child transmission"},"content":{"rendered":"

Polly Clayden, HIV i-Base<\/strong><\/p>\n

A poster from Susan Eshleman and coworkers, reported findings from a study looking at the association between HIV-1 replication capacity and HIV-1 mother to child (MTCT) transmission, among antiretroviral naive HIV positive Malawian women, enrolled in the NVAZ trial of women who presented late for delivery<\/strong> [1,2].<\/p>\n

This group of subtype C HIV positive women received no antiretroviral prophylaxis. The infants were randomised to receive single dose nevirapine or single dose nevirapine plus one week AZT.<\/p>\n

The authors classified women as transmitters if their infants were diagnosed with HIV at birth or by 6-8 weeks, and non-transmitters if their infants were uninfected at 6-8 weeks of age. Fifty two transmitters and 48 non-transmitters were randomly selected from the NVAZ group of 172 transmitters and 780 non-transmitters.<\/p>\n

Replication capacity was measured using a modified version of the PhenoSense HIV test. Plasma samples were collected at time of delivery.<\/p>\n

Replication capacity results were determined for 49 transmitters and 47 non- transmitters. The mean replication capacity for the maternal plasma samples was 32% (standard deviation = 20%). The mean replication capacity was higher for transmitters 35.3% vs non-transmitters 27.4% (p = 0.02 ), as was mean maternal viral load 5.1 log10 vs 4.6 log 10 (p=0.001).<\/p>\n

In a multivariate model, a higher log10 replication capacity was associated with MTCT (OR = 6.60, 95%CI 1.23 to 35.31, p= 0.03), adjusting for log10 delivery viral load (OR = 2.77, 95% CI 1.38 to 5.57, p = 0.0043), maternal age (OR = 1.01, 95%CI 0.88 to 1.16, p = 0.89), parity (OR = 1.34, 95%CI 0.90 to 2.00, p= 0.15), and infant regimen (OR = 0.61, 95%CI 0.23 to 1.61, p = 0.31).<\/p>\n

The authors noted that the proportion of infants receiving single dose nevirapine alone was higher among the transmitter group as found in the NVAZ trial.<\/p>\n

In this group of Malawian subtype C HIV positive women whose infants received single dose nevirapine or single dose nevirapine plus AZT, maternal viral load was associated with MTCT. The authors wrote: \u0093Further studies are needed to confirm the association of replication capacity and HIV-1 transmission in diverse HIV-1 subtypes, in different clinical settings and with different routes of HIV-1 transmission. These results also suggest that determinants in the HIV-1 gag\/pol region influence HIV-1 MTCT, since this is the only region of the patients HIV-1 genome inserted into the resistance test vector in the replication capacity assay\u0094<\/p>\n

References:<\/p>\n

    \n
  1. NVAZ Study. Lancet 2003;362;1171-7.<\/li>\n
  2. Eshleman SH, Chen S, Lie Y et al. Association of HIV-1 replication capacity with HIV-1 mother-to-child transmission among ART-naive Malawian women: NVAZ trial. 13thCROI, Denver, 2006. Abstract 719.<\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Polly Clayden, HIV i-Base A poster from Susan Eshleman and coworkers, reported findings from a study looking at the association between HIV-1 replication capacity and HIV-1 mother to child (MTCT) transmission, among antiretroviral naive HIV positive Malawian women, enrolled in …<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,35],"tags":[60],"class_list":["post-3423","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-pmtct-and-maternal-health","tag-croi-2006"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3423","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3423"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3423\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3423"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3423"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3423"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}