{"id":34574,"date":"2018-07-20T09:55:49","date_gmt":"2018-07-20T09:55:49","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=34574"},"modified":"2018-07-20T09:55:49","modified_gmt":"2018-07-20T09:55:49","slug":"what-to-watch-hiv-cure-related-research-at-aids-2018","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/34574","title":{"rendered":"What to watch: HIV cure-related research at AIDS 2018"},"content":{"rendered":"

\"\"Richard Jefferys, TAG<\/strong><\/p>\n

The following workshops, sessions and presentations at the upcoming AIDS 2018 conference<\/a> in Amsterdam. showing the breadth and diversity of cure-related research this year.<\/strong><\/p>\n

Hyperlinks are included where available, but searching the online programme for relevant key words will provide links for others.<\/p>\n

This listing does not include the dozens – perhaps hundreds – of cure-related posters that will also be presented.<\/p>\n

\n

HIV Cure Research with the Community Workshop<\/a>
\nPre-Conference Meeting
\nRoom E105\u2013108, RAI, Amsterdam, Netherlands
\nSaturday July 21, 2018, 9:00-18:00<\/p>\n

Strategies for diagnosing and managing acute HIV infection in the context of PrEP and immediate ART<\/a>
\nMOSA52
\nSession Type: Non-Commercial Satellite
\nVenue: Hall 11B
\nMonday July 23, 17:00 – 19:00<\/p>\n

17:20\u00a0MOSA5203
\nAcute HIV infection and HIV cure
\nThumbi Ndung\u2019u, Africa Health Research Institute, University of KwaZulu-Natal, South Africa<\/p>\n

Biomedical research innovations in the prevention, remission and cure of HIV\/AIDS
\n<\/a>Code: MOSA48
\nSession Type: Major Industry Sponsor Satellite
\nVenue: Elicium 2
\nMonday July 23, 17:00 – 19:00<\/p>\n

17:05 MOSA4802
\n30 years of progress in the field of HIV\/AIDS
\nAnthony Fauci, National Institutes of Health (NIH), United States<\/p>\n

18:05\u00a0MOSA4802
\nPassive immunization\/bNAbs monoclonals both for prevention and treatment
\nPenny Moore, University of the Witwatersrand \/ National Institute for Communicable Diseases, South Africa<\/p>\n

18:25 MOSA4802
\nRemission and cure efforts
\nJavier Martinez-Picado, AIDS Research Institute irsiCaixa, Spain<\/p>\n

Besieging the reservoir and kicking it where it hurts<\/a>
\nCode: TUPDA01
\nSession Type: Oral Poster Discussion Session Track A \u2013 Basic and translational research
\nVenue: G104-105
\nTuesday July 24, 13:00 – 14:00<\/p>\n

13:00\u00a0TUPDA0101
\nAssociation between immunogenetic factors and post-treatment control of HIV-1 infection. ANRS VISCONTI and PRIMO studies
\nAsier Sa\u00e9z-Cirion, Insitut Pasteur, France<\/p>\n

13:05\u00a0TUPDA0102
\nHCV treatment with direct-acting antivirals (DAAs) in HIV\/HCV coinfected subjects affects the dynamics of the HIV-1 reservoir
\nNatalia Laufer, INBIRS Institute (UBA-CONICET), Argentina<\/p>\n

13:10\u00a0TUPDA0103
\nIL-10 contributes to, and is a biomarker for, viral persistence in ART-treated, SIV-infected rhesus macaques
\nMirko Paiardini, Emory University, United States<\/p>\n

13:15\u00a0TUPDA0104
\nFollicular CD8+ T-cells in gut-associated lymphoid tissue are associated with lower HIV-1 reservoir in the terminal ileum after ART initiated during primary HIV infection
\nJohn Patrick Thornhill, Imperial College London, United Kingdom<\/p>\n

13:20\u00a0TUPDA0105
\nHIV-1 reservoir diversity and genetic compartmentalization in blood and testis
\nRosalie Ponte, The Research Institute of the McGill University Health Centre, Canada<\/p>\n

Strategies for cure: Pitfalls, possibilities and promise<\/a>
\nCode: TUAA02
\nSession Type: Oral Abstract Session Track A \u2013 Basic and translational research
\nVenue: E102
\nTuesday July 24, 16:30 – 18:00<\/p>\n

16:30\u00a0TUAA0201
\nTherapeutic Vaccines for Cure
\nSteven Deeks, University of California, United States<\/p>\n

17:00\u00a0TUAA0203
\nDominant HIV DNA populations present in different T-cell subsets before stem cell transplantation persist in tissues early after transplantation with CCR5\u039432 stem cells
\nAnnemarie Wensing, University Medical Center Utrecht, Netherlands<\/p>\n

17:15\u00a0TUAA0204
\nRapid rebound of a highly replication competent preexisting CXCR4-tropic HIV variant after allogeneic stem cell transplantation with CCR5\u039432 stem cells
\nMonique Nijhuis, University Medical Center Utrecht, Netherlands<\/p>\n

17:30\u00a0TUAA0205
\nModular gene therapy vectors for gene therapy cure in resting immune cells
\nAndrew Wong, The University Of New South Wales Sydney, Australia<\/p>\n

Building bridges from scientific innovation to implementation<\/a>
\nCode: WEPL01
\nPlenary Session
\nVenue: Hall 12
\nWednesday July 25, 08:45 – 10:30<\/p>\n

08:55 WEPL0105
\nThe newest science in the search for a cure and vaccine
\nBrad Jones, Weill Cornell Medicine and The George Washington University, United States<\/p>\n

Poking, prodding and purging the final reservoir frontier<\/a>
\nWEAA01
\nSession Type: Oral Abstract Session Track A \u2013 Basic and translational research
\nVenue: G104-105
\nWednesday July 25, 11:00 – 12:30<\/p>\n

11:00\u00a0WEAA0101
\nChidamide reactivates and diminishes latent HIV-1 DNA in patients on suppressive antiretroviral therapy
\nWen Kang, Tangdu Hospital affiliated to The Fourth Military Medical University, China<\/p>\n

11:15\u00a0WEAA0102
\nThe antiretroviral CCR5-inhibitor maraviroc effectively reverses HIV latency by phosphorylation of Nf-\u03baB
\nJori Symons, The Peter Doherty Institute for Infection and Immunity, The University of Melbourne, Australia<\/p>\n

11:30\u00a0WEAA0103
\nActivation of latent HIV and SIV RNA transcription in vitro and in vivo in ART suppressed SIV-infected rhesus macaques by the Ingenol-based protein kinase C agonist, GSK445A
\nAfam Okoye, Oregon Health and Science University, United States<\/p>\n

11:45\u00a0WEAA0104
\nThe RNA-binding proteins, SRP14 and HMGB3 play a crucial role in controlling HIV replication and latency
\nGeorges Khoury, Peter Doherty Institute, Australia<\/p>\n

12:00\u00a0WEAA0105
\nUsing the PPARg antagonism to block\/lock HIV reactivation in Th17 cells
\nPetronela Ancuta, Universite de Montreal and CHUM Research Centre, Canada<\/p>\n

Acute infection and viral reservoir<\/a>
\nWEPDB01
\nSession Type: Oral Poster Discussion Session Track B \u2013 Clinical research
\nVenue: E102
\nWednesday July\u00a025, 13:00 – 14:00<\/p>\n

13:00\u00a0WEPDB0101
\nValidation of Alere TM q HIV-1\/2 detect for detection of acute HIV infection at Anonymous Clinic, The Thai Red Cross AIDS Research Centre
\nIrin Srila-Or, The Thai Red Cross AIDS Research Centre, Thailand<\/p>\n

13:05\u00a0WEPDB0102
\nFavorable clinical phenotype reached in less than half of people treated in acute HIV infection
\nJintanat Ananworanich, The Henry M. Jackson Foundation for the Advancement of Military Medicine, United States<\/p>\n

13:10\u00a0WEPDB0103
\nIncreasing contribution of integrated forms to total HIV1-DNA in blood, in primary infection during natural history – ANRS PRIMO and SEROCO cohorts
\nV\u00e9ronique Avettand-Fenoel, Universit\u00e9 Paris Descartes, France<\/p>\n

13:15\u00a0WEPDB0104
\nIntermittent viremia after treatment interruption increased risk of ART resumption in post-treatment HIV-1 controllers. ANRS VISCONTI study
\nLaurent Hocqueloux, CHR d’Orl\u00e9ans – La Source, France<\/p>\n

13:20\u00a0WEPDB0105
\nAuranofin plus nicotinamide impact HIV reservoir among ART suppressed HIV individuals
\nRicardo Sobhie Diaz, Federal University of Sao Paulo, Brazil<\/p>\n

All fired up: Tackling inflammation<\/a>
\nWEPDA01
\nSession Type: Oral Poster Discussion Session Track A \u2013 Basic and translational research
\nVenue: Hall 11B
\nWednesday July 25, 13:00 – 14:00<\/p>\n

13:10 WEPDA0103
\nPersistence of myeloid cell-associated inflammation in HIV-infected children after 8 years on early initiated therapy – the key role players in HIV persistence?
\nShalena Naidoo, Stellenbosch University, South Africa<\/p>\n

Killers or helpers: The double life of T cells<\/a>
\nWEAA02
\nSession Type: Oral Abstract Session Track A \u2013 Basic and translational research
\nVenue: Hall 11B
\nWednesday July 25, 14:30 – 16:00<\/p>\n

14:30 WEAA0201
\nIncrease in restriction factor expression in response to viral rebound after analytical treatment interruption in HIV-infected patients
\nMarie-Ang\u00e9lique De Scheerder, UZ Gent, Belgium<\/p>\n

14:45 WEAA0202
\nRhCMV-induced, SIV-specific MHC-E-restricted T cells recognize SIV through the T cell receptor
\nShaheed Abdulhaqq, Oregon Health and Science University, United States<\/p>\n

15:00 WEAA0203
\nGenetic factors leading to loss of viral control in HIV elite controller patients
\nJos\u00e9 M. Benito, Instituto de Investigaci\u00f3n Sanitaria Fundaci\u00f3n Jim\u00e9nez D\u00edaz, Universidad Aut\u00f3noma de Madrid (IIS-FJD, UAM), Spain<\/p>\n

15:15 WEAA0204
\nFrequent generation of HIV broadly neutralizing antibodies in infected children is associated with both increased help and regulation within germinal centers
\nJulia Roider, University of Oxford, South Africa<\/p>\n

15:30 WEAA0205
\nInitiation of antiretroviral therapy during hyperacute HIV infection preserves germinal center T follicular (GCTfh) helper cell function
\nZaza Ndhlovu, University of KwaZulu Natal, South Africa<\/p>\n

Eliminating HIV latency: Shock and kill or block and lock?<\/a>
\nWESY09
\nSession Type: Symposia Session
\nVenue: Hall 11B
\nWednesday July\u00a025, 16:30 – 18:00<\/p>\n

16:44 WESY0902
\nIntroductory comments
\nMaureen Goodenow, U.S. DHHS National Institutes of Health, Office of AIDS Research, United States<\/p>\n

16:49 WESY0903
\nUnderstanding HIV persistence \u2013 do defective viruses matter?
\nYa-Chi Ho, Yale University School of Medicine, United States<\/p>\n

17:06 WESY0904
\nLow level transcription on ART \u2013 implications for latency elimination
\nSteve Yukl, University of California, United States<\/p>\n

17:23 WESY0905
\nTLR agonists and latency reversal: can they both shock and kill?
\nMartin Tolstrup, Aarhus University, Denmark<\/p>\n

17:40\u00a0WESY0906
\nBlock and lock using gene silencing
\nAnthony Kelleher, The University of New South Wales (UNSW), Australia<\/p>\n

17:57\u00a0WESY0907
\nUnderstanding community participation in cure studies: what scientists need to know
\nCipriano Martinez, National Association for People Living with HIV in Australia, Australia<\/p>\n

Broadly neutralizing antibodies (bNabs): Towards a cure and vaccine<\/a>
\nTHSY04
\nSession Type: Symposia Session
\nVenue: G104-105
\nThursday July\u00a026, 11:00 – 12:30<\/p>\n

11:05 THSY0402
\nFactors determining bNab elicitation in HIV-infected individuals during natural infection: Challenges a vaccine has to overcome
\nAlexandra Trkola, Leiterin Group Trkola, Switzerland<\/p>\n

11:25\u00a0THSY0403
\nMaturation of bNabs in HIV-1 infected patients (specifics of B-cell maturation), what is different from other infections?
\nMichel Nussenzweig, The Rockefeller University, United States<\/p>\n

11:45 THSY0404
\nInduction of bNabs by vaccines: where do we stand, what is being needed for success
\nRogier Sanders, AMC, Netherlands<\/p>\n

12:05 THSY0405
\nbNabs for clinical use: antiviral activity and effector functions other than neutralization
\nLynn Morris, University of the Witwatersrand, South Africa<\/p>\n

How Far are We from HIV Remission?<\/a>
\nCode: THSA14
\nSession Type: Non-Commercial Satellite
\nVenue: Hall 11A
\nThursday July 26, 18:30 – 20:30<\/p>\n

18:35 THSA1402
\nAn Update on Post-Treatment Controllers in France and Worldwide
\nLaurent Hocqueloux, CHR d’Orl\u00e9ans – La Source, France<\/p>\n

18:50 THSA1403
\nInsights on Mechanisms of Post-Treatment Control
\nAsier Sa\u00e9z-Cirion, Insitut Pasteur, France<\/p>\n

19:10 THSA1405
\nLessons from Research Interventions aiming at HIV Remission<\/p>\n

19:30 THSA1406
\nVery early ART Initiation during “Hyperacute” HIV Infection
\nTimothy Henrich, University of California at San Francisco ( UCSF), United States<\/p>\n

19:45\u00a0THSA1407
\nStem Cell Transplantations: ICISTEM
\nMonique Nijhuis, University Medical Center Utrecht, Netherlands<\/p>\n

20:00\u00a0THSA1408
\nInterventions with broadly neutralizing antibodies (bNAb)
\nMichel Nussenszweig, Howard Hughes Institute, The Rockefeller University, United States<\/p>\n

20:15\u00a0THSA1409
\nHIV Remission Research: Expectations and Questioning
\nRichard Jefferys, Treatment Action Group, United States<\/p>\n

20:45 THSA1411
\nConcluding Remarks
\nFran\u00e7oise Barr\u00e9-Sinoussi, Institut Pasteur, France<\/p>\n<\/div>\n

Source<\/p>\n

TAG Basic Science Blog.\u00a0HIV Cure-Related Research at AIDS 2018. (19 July 2018)
\nhttp:\/\/tagbasicscienceproject.typepad.com\/tags_basic_science_vaccin\/2018\/07\/hiv-cure-related-research-at-aids-2018.html<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

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