{"id":3516,"date":"2000-05-15T08:25:13","date_gmt":"2000-05-15T08:25:13","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3516"},"modified":"2014-07-01T13:08:03","modified_gmt":"2014-07-01T13:08:03","slug":"gm-csf-beneficial-for-patients-with-advanced-hiv-disease","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3516","title":{"rendered":"GM-CSF beneficial for patients with advanced HIV disease"},"content":{"rendered":"<p><strong>In a phase III multicentre trial of patients with advanced HIV disease, granulocyte-macrophage colony-stimulating factor (GM-CSF) significantly increased CD4 T-cell and neutrophil counts, delayed the time to first infection, and reduced the incidence of overall infection.<\/strong><\/p>\n<p>Dr Jonathan B. Angel, of the University of Ottawa, Ontario, Canada, and colleagues from the Leukine\/HIV Study Group randomised 309 patients to receive either placebo or GM-CSF for 24 weeks. The patients&#8217; CD4 cell counts were between 50-100 cells\/mm3, they had previously had an AIDS-defining illness, and they were on stable antiretroviral therapy.<\/p>\n<p>Adjuvant GM-CSF significantly increased CD4 and neutrophil counts after 1, 3, and 6 months of therapy, as reported in the March 10th issue of AIDS. Sixty-seven percent of patients receiving GM-CSF developed an infection, compared with 78% of patients receiving placebo. In addition, GM-CSF delayed the time to first infection to 97 days, compared with 56 days for placebo<\/p>\n<p>The study showed that there were no differences between groups in cumulative opportunistic infections or changes in HIV RNA.<\/p>\n<p>The authors suggest that the addition of GM-CSF to an effective regimen of antiretroviral therapy could delay virologic failure. &#8216;Whether the ability of GM-CSF to maintain viral suppression as observed in the advanced HIV population will translate to individuals with earlier stages of HIV disease remains to be evaluated.&#8217;<\/p>\n<p>Reference:<\/p>\n<p>Angel J et al. Phase III study of granulocyte-macrophage colony-stimulating factor in advanced HIV disease: effect on infections, CD4 cell counts and HIV suppression.\u00a0AIDS 2000;14:387-395.<br \/>\n<a href=\"http:\/\/journals.lww.com\/aidsonline\/Fulltext\/2000\/03100\/Phase_III_study_of_granulocyte_macrophage.12.aspx\">http:\/\/journals.lww.com\/aidsonline\/Fulltext\/2000\/03100\/Phase_III_study_of_granulocyte_macrophage.12.aspx<\/a><\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>In a phase III multicentre trial of patients with advanced HIV disease, granulocyte-macrophage colony-stimulating factor (GM-CSF) significantly increased CD4 T-cell and neutrophil counts, delayed the time to first infection, and reduced the incidence of overall infection. Dr Jonathan B. Angel, &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-3516","post","type-post","status-publish","format-standard","hentry","category-treatment-strategies"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3516","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3516"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3516\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3516"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3516"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3516"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}