{"id":3519,"date":"2000-05-15T08:28:39","date_gmt":"2000-05-15T07:28:39","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3519"},"modified":"2014-07-01T13:08:33","modified_gmt":"2014-07-01T13:08:33","slug":"most-reconstituted-cd4-cells-naive-after-haart-in-children-with-hiv","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3519","title":{"rendered":"Most reconstituted CD4 cells naive after HAART in children with HIV"},"content":{"rendered":"<p><strong>Immune repopulation after highly active antiretroviral therapy (HAART) is different in children than in adults, according to a report in the April 15th issue of the Lancet.<\/strong><\/p>\n<p>In particular, reconstituted CD4 cells in adults tend to be memory cells carrying the CD45RO marker, while new CD4 cells in children tend to be naive T cells carrying the CD45RA marker, Dr D M Gibb, of the Medical Research Council Clinical Trials Unit, in London, UK, and other investigators for the Paediatric European Network for Treatment of AIDS Steering Committee say in the journal.<\/p>\n<p>The investigators monitored immune repopulation in 25 vertically HIV-infected children for 1 year after HAART. Treatment with HAART brought about a 3-log reduction in plasma HIV RNA load that lasted for at least 1 year. Treatment also induced a &#8216;substantial increase in median CD4 cells,&#8217; the authors write, from 403 cells\/mm3 at baseline to 650 cells\/mm3 at 24 weeks and 631 cells\/mm3 at 48 weeks.<\/p>\n<p>At 48 weeks, 71% of the reconstituted CD4 cells in these children were naive cells, Dr Gibb and colleagues say. This contrasts with adult patients, in whom &#8216;the initial rise in CD4 cells after HAART is due to expansion of CD45RO memory cells.&#8217; The team attributes this difference to the presence of functioning thymus tissue in children.<\/p>\n<p>The findings &#8216;raise important questions about therapeutic strategies to be followed in children,&#8217; the investigators note. &#8216;Compared with adults, the presence of a functioning thymus in children may allow alternative approaches to treatment, including removal of memory cells, the major reservoir of HIV-1, which would not be possible in adults.&#8217;<\/p>\n<p>Reference:<\/p>\n<p>Lancet 2000;355:1331-1332.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Immune repopulation after highly active antiretroviral therapy (HAART) is different in children than in adults, according to a report in the April 15th issue of the Lancet. In particular, reconstituted CD4 cells in adults tend to be memory cells carrying &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[],"class_list":["post-3519","post","type-post","status-publish","format-standard","hentry","category-paediatric-care"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3519","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3519"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3519\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3519"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3519"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3519"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}