{"id":35558,"date":"2019-01-21T06:43:59","date_gmt":"2019-01-21T06:43:59","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=35558"},"modified":"2019-01-22T07:38:07","modified_gmt":"2019-01-22T07:38:07","slug":"hiv-is-associated-with-higher-biological-age-compared-to-chronological-age","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/35558","title":{"rendered":"HIV is associated with higher biological age compared to chronological age"},"content":{"rendered":"

Simon Collins, HIV i-Base<\/strong><\/p>\n

A new prospective cross-sectional cohort study reports that people older than 45 commonly have a higher biological age compared to their chronological age, and that the difference is higher for HIV positive people compared to a matched HIV negative control group.<\/strong><\/p>\n

The study was reported by Davide De Francesco and colleagues from the COBRA collaboration and published in the journal AIDS.<\/p>\n

The analysis included 134 HIV positive participants on suppressive ART, 79 lifestyle-comparable\u00a0HIV-negative participants >45 years old, and a further control group of 35 age-matched blood donors (who are screened for other infections and social and lifestyle behaviour\u00ad, including sexual risk and travel).<\/p>\n

Biological age was calculated using 10 age-related biomarkers that have been previously shown to be best predictors of chronological age in a large European study. Results were adjusted for HIV history (CD4, CD8, viral load, ARVs) and other health-related social demographics including age, sex, sexuality, education, smoking, alcohol and recreational drugs, CMV, HBV and HCV.<\/p>\n

All HIV positive participants were on effective ART with undetectable viral load (<50 copies\/mL), with median CD4 count of 618 (IQR: 472 to 806) cells\/mm3. Approximately one third had a history of previous AIDS.<\/p>\n

The HIV positive participants had an average biological age that was 13.2 years older than their chronological age (95%CI: 11.6 to 14.9) compared to a biological age in the HIV negative control group that was 5.5 years older (95%CI: 3.8 to 7.2), both p<0.001. Biological age was also significantly higher for both groups compared to the blood donor controls whose biological age was \u20137.0 years younger than their chronological age (95%CI: \u22124.1 to \u22129.9) (both\u00a0p < 0.001). <\/span><\/p>\n

Higher biological age was significantly associated with chronic HBV (p=0.008), higher anti-CMV IgG titer (p=0.002) and higher CD8 T cells (p=0.02), independently of\u00a0HIV status.<\/p>\n

Among\u00a0HIV positive participants, multivariate analysis showed CD4 nadir <200 cells\/mm3was associated with biological age increase of 3.5 years (95%CI: 0.1 to 6.8).<\/p>\n

The only HIV drug that was significantly associated with higher biological age (by 0.1 (95%CI: 0.06\u20130.2) years for each additional month of exposure) was the protease inhibitor saquinavir. There was a lack of association with mitochondrial toxic ARVs (d4T, ddI and ddC). However, the discussion in the paper notes this might be a limitation of the biomarkers (as there was also no association with current or past cigarette smoking).<\/p>\n

The paper concludes that the results show HIV is more associated with accentuated rather than accelerated ageing, but that longitudinal follow-up is required to really answer this question.<\/p>\n

The paper defined accentuated ageing as an increased burden of ageing-related damage while the year-on-year damage remains static over time. Accelerated ageing is defined as occurring when age-related complications occur earlier than expected with a progressive increase in the rate of decline.<\/p>\n

Reference:
\nDe Francesco D et al on behalf of the Co-morbidity in Relation to AIDS (COBRA) Collaboration. Do people living with HIV experience greater age advancement than their HIV-negative counterparts? AIDS 33(2); 259\u2013268. doi: 10.1097\/QAD.0000000000002063. (01 February 2019). Full open access.
\nhttps:\/\/journals.lww.com\/aidsonline\/Fulltext\/2019\/02010\/Do_people_living_with_HIV_experience_greater_age.9.aspx<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base A new prospective cross-sectional cohort study reports that people older than 45 commonly have a higher biological age compared to their chronological age, and that the difference is higher for HIV positive people compared to a …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[170],"tags":[],"class_list":["post-35558","post","type-post","status-publish","format-standard","hentry","category-ageing-and-life-expectancy"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/35558","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=35558"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/35558\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=35558"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=35558"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=35558"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}