{"id":3634,"date":"2000-06-15T21:57:47","date_gmt":"2000-06-15T21:57:47","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3634"},"modified":"2014-07-01T12:57:29","modified_gmt":"2014-07-01T12:57:29","slug":"cd8-cell-antiviral-factors-not-restricted-to-cytotoxic-t-cells-induced-during-hiv","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3634","title":{"rendered":"CD8+-cell antiviral factors not restricted to cytotoxic T cells induced during HIV"},"content":{"rendered":"

T cells induced during HIV CD8+-cell antiviral factors are not restricted to HIV-specific CD8+ cells, according to a report published in the May issue of the Journal of Virology. The report implies, according to the researchers, that CD8+ T cells, regardless of specificity, contribute to this effect through cell antiviral factors that are present after T-cell receptor stimulation occurs.<\/strong><\/p>\n

Dr Yves Riviere, of the Institut Pasteur, in Paris, France, and colleagues demonstrated that, using an HIV Nef-specific cytotoxic-T-lymphocyte (CTL) line and autologous CD4+ T cells infected with a nef-deleted HIV-1 virus, viral suppression did ‘not require the presence of the specific antigen during the effector phase.’<\/p>\n

The group also used an Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocyte line from an HIV-negative subject to show that ‘the ability to inhibit HIV replication in a noncytolytic manner is not restricted to HIV-specific effector cells.’ They found that EBV-specific CTL were as effective as ‘HIV-specific effectors in suppressing R5 or X4 HIV-1 strain replication in vitro.’<\/p>\n

In addition, Dr Riviere’s team found that HIV suppressive activity was ‘detectable for up to 14 days following stimulation of EBV-specific CD8+ cells with the cognate epitope peptide.’<\/p>\n

The group also reports that after infection of ‘CEM cells with an X4 strain of HIV-1, EBV-specific CTL line supernatant containing HIV-suppressive activity did not block virus entry but was shown to interfere with virus replication after the first template switching of reverse transcription.’<\/p>\n

The researchers suggest that in HIV infection the ‘production of antiviral soluble factors by CD8+ T cells could be of importance in the in vivo control of viral latency.’<\/p>\n

T cells induced during HIV CD8+-cell antiviral factors are not restricted to HIV-specific CD8+ cells, according to a report published in the May issue of the Journal of Virology. The report implies, according to the researchers, that CD8+ T cells, regardless of specificity, contribute to this effect through cell antiviral factors that are present after T-cell receptor stimulation occurs.<\/p>\n

Dr Yves Riviere, of the Institut Pasteur, in Paris, France, and colleagues demonstrated that, using an HIV Nef-specific cytotoxic-T-lymphocyte (CTL) line and autologous CD4+ T cells infected with a nef-deleted HIV-1 virus, viral suppression did ‘not require the presence of the specific antigen during the effector phase.’<\/p>\n

The group also used an Epstein-Barr virus (EBV)-specific cytotoxic T-lymphocyte line from an HIV-negative subject to show that ‘the ability to inhibit HIV replication in a noncytolytic manner is not restricted to HIV-specific effector cells.’ They found that EBV-specific CTL were as effective as ‘HIV-specific effectors in suppressing R5 or X4 HIV-1 strain replication in vitro.’<\/p>\n

In addition, Dr Riviere’s team found that HIV suppressive activity was ‘detectable for up to 14 days following stimulation of EBV-specific CD8+ cells with the cognate epitope peptide.’<\/p>\n

The group also reports that after infection of ‘CEM cells with an X4 strain of HIV-1, EBV-specific CTL line supernatant containing HIV-suppressive activity did not block virus entry but was shown to interfere with virus replication after the first template switching of reverse transcription.’<\/p>\n

The researchers suggest that in HIV infection the ‘production of antiviral soluble factors by CD8+ T cells could be of importance in the in vivo control of viral latency.’<\/p>\n

Source: Reuters Health<\/p>\n

Reference:<\/p>\n

J Virol 2000;74:4456-4464.<\/p>\n","protected":false},"excerpt":{"rendered":"

T cells induced during HIV CD8+-cell antiviral factors are not restricted to HIV-specific CD8+ cells, according to a report published in the May issue of the Journal of Virology. The report implies, according to the researchers, that CD8+ T cells, …<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-3634","post","type-post","status-publish","format-standard","hentry","category-basic-science-and-immunology"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3634"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3634\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}