{"id":3641,"date":"2000-06-15T22:03:02","date_gmt":"2000-06-15T21:03:02","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3641"},"modified":"2014-07-01T12:56:14","modified_gmt":"2014-07-01T12:56:14","slug":"accelerated-bone-mineral-loss-in-hiv-infected-patients-receiving-potent-antiretroviral-therapy","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3641","title":{"rendered":"Accelerated bone mineral loss in HIV-positive patients receiving potent antiretroviral therapy"},"content":{"rendered":"<h2>Abstract<\/h2>\n<p><strong>Background:<\/strong> The use of highly active antiretroviral therapy (HAART) has been associated with multiple metabolic complications whose pathogenesis is poorly understood at the present time.<\/p>\n<p><strong>Methods:<\/strong> We performed a cross-sectional analysis of whole-body, lumbar spine (L1-L4) and proximal femur bone mineral density in 112 male subjects (HIV-infected patients on HAART that included a protease inhibitor, HIV-infected patients not receiving a protease inhibitor and healthy seronegative adults) using dual energy x-ray absorptiometry.<\/p>\n<p><strong>Results:<\/strong> Men receiving protease inhibitors had a higher incidence of osteopenia and osteoporosis according to World Health Organization definitions: relative risk = 2.19 (95% confidence interval 1.13-4.23) (P = 0.02). Subjects receiving protease inhibitors had greater central: appendicular adipose tissue ratios than the other two groups (P &lt; 0.0001). There was no relationship between the central: appendicular fat ratio and the lumbar spine or proximal femur bone mineral density t- or z- scores, suggesting that osteoporosis and body fat redistribution are independent side effects of HAART.<\/p>\n<p><strong>Conclusions:<\/strong> Osteopenia and osteoporosis are unique metabolic\u00a0 complications associated with protease inhibitor-containing potent antiretroviral regimens, that appear to be independent of adipose tissue maldistribution.<\/p>\n<p>Reference:<\/p>\n<p>Tebas P, Powderly WG, Claxton S et al. AIDS 2000 Mar 10;14(4):F63-7.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Background: The use of highly active antiretroviral therapy (HAART) has been associated with multiple metabolic complications whose pathogenesis is poorly understood at the present time. Methods: We performed a cross-sectional analysis of whole-body, lumbar spine (L1-L4) and proximal femur &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-3641","post","type-post","status-publish","format-standard","hentry","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3641","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3641"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3641\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3641"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3641"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3641"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}