{"id":3666,"date":"2000-07-16T07:36:49","date_gmt":"2000-07-16T06:36:49","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3666"},"modified":"2014-07-01T12:43:48","modified_gmt":"2014-07-01T12:43:48","slug":"nevirapine-daily-exposure-for-daily-400-mg-dose-compared-to-200-mg-twice-daily","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3666","title":{"rendered":"Nevirapine daily exposure for daily 400 mg dose compared to 200 mg twice-daily"},"content":{"rendered":"<p><strong>When administered to HIV-infected patients, a daily 400-mg dose of nevirapine gives an equivalent daily exposure as a 200 mg twice-daily dose does, according to researchers in the Netherlands. Dr Rolf P. G. van Heeswijk, from Slotervaart Hospital, in Amsterdam, and colleagues randomized 20 HIV-infected patients already using nevirapine to either continue receiving the drug at 200 mg twice a day or to switch to a 400-mg dose once a day.<\/strong><\/p>\n<p>After 2 weeks, the researchers measured the steady-state plasma pharmacokinetics of nevirapine over a 24-hour period. Patients were then switched to the other dosing regimen for 2 weeks, after which the researchers again evaluated the pharmacokinetics of the drug. As assessed by the area under the plasma concentration versus time curve, nevirapine exposure was similar between the 2 dosing regimens, Dr van Heeswijk&#8217;s group reports in the May 26th issue of AIDS. Other pharmacokinetic parameters such as the time to maximal plasma concentration, plasma elimination half-life, apparent oral clearance, and apparent volume of distribution also did not significantly differ between the 2 regimens.<\/p>\n<p>However, the investigators note that the maximal plasma concentration was higher, and the minimal plasma concentration was lower, with the once-daily regimen compared with the twice-daily regimen. &#8216;The clinical implications of these differences remain to be established,&#8217; the authors write, noting that &#8216;thus far, no relationship between (maximum) plasma nevirapine concentrations and toxicity has been discerned.&#8217;<\/p>\n<p>The results of this study demonstrate that the daily exposure to nevirapine is not significantly different between a dosing regimen of 400 mg once daily and 200 mg twice daily,&#8217; they conclude.<\/p>\n<p>Source: Reuters Health<\/p>\n<h3>Comment<\/h3>\n<p><strong>This report correctly states that no relationship has been established between maximum Nevirapine concentrations and toxicity. Caution should be observed, however, as there has been a relationship established between minimal plasma concentration (Cmin or trough) of nevirapine and virological response. Lower trough levels were observed with once daily dosing.<\/strong><\/p>\n<p>Reference:<\/p>\n<p>AIDS 2000;14:F77-F82.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>When administered to HIV-infected patients, a daily 400-mg dose of nevirapine gives an equivalent daily exposure as a 200 mg twice-daily dose does, according to researchers in the Netherlands. Dr Rolf P. G. van Heeswijk, from Slotervaart Hospital, in Amsterdam, &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-3666","post","type-post","status-publish","format-standard","hentry","category-antiretrovirals"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3666","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3666"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3666\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3666"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3666"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3666"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}