{"id":36844,"date":"2019-11-15T08:43:43","date_gmt":"2019-11-15T08:43:43","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=36844"},"modified":"2019-11-15T15:13:12","modified_gmt":"2019-11-15T15:13:12","slug":"eacs-launch-major-update-to-european-treatment-guidelines-november-2019","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/36844","title":{"rendered":"EACS launch major update to European Treatment Guidelines (November 2019)"},"content":{"rendered":"<p class=\"HTBsubhead3authorcredit\"><strong><span lang=\"EN-US\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-36811\" src=\"https:\/\/i-base.info\/htb\/wp-content\/uploads\/2019\/11\/EACS-2019-logo-1-300x186.png\" alt=\"\" width=\"300\" height=\"186\" srcset=\"https:\/\/i-base.info\/htb\/wp-content\/uploads\/2019\/11\/EACS-2019-logo-1-300x186.png 300w, https:\/\/i-base.info\/htb\/wp-content\/uploads\/2019\/11\/EACS-2019-logo-1.png 429w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\">Every two years EACS publish a major update to their clinical guidelines, with minor revisions on alternate years. This is an international collaboration by over 60 leading European HIV doctors with additional input from experts in other fields. <\/span><\/strong><\/p>\n<p><span lang=\"EN-US\"><strong><img loading=\"lazy\" decoding=\"async\" class=\"alignright wp-image-36845\" src=\"https:\/\/i-base.info\/htb\/wp-content\/uploads\/2019\/11\/EACS-guigeline-cover-223x300.png\" alt=\"\" width=\"179\" height=\"238\" \/><\/strong>This year the major update includes many new sections, taking the print edition up to 260 pages, with additional information online including video links to\u00a0 EACS management lectures.<br \/>\n<\/span><a href=\"https:\/\/eacs.sanfordguide.com\" rel=\"noopener noreferrer\"><span lang=\"EN-US\">https:\/\/eacs.sanfordguide.com<\/span><\/a><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">The guidelines are also available on a free app for Apple and Android devices.<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">There are <\/span>six main sections: a general section of all major issues, recommendations for ART, drug-drug interactions, co-morbidities, hepatitis coinfection and opportunistic diseases.<\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">In addition to the most widely applied sections, for example, on preferred drugs for first-line ART, or for managing virological rebound, there are new reference sections for use in specific populations. This edition includes new tables for managing drug interactions for transgender people, for older people and for those with reduced kidney function.<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">The guidelines are therefore developed as reference resource to cover the broad diversity of adults living with HIV &#8211; with different ages, genders and complex treatment histories.<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">The whole guidelines have been updated to include new ARVs with notes for different combinations and patient circumstances and removal of older drugs (including older PIs, ddI and d4T).<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Other selected changes to this edition are listed below.<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">A full list of changes at this link:<br \/>\n<\/span><a href=\"https:\/\/eacs.sanfordguide.com\/contents\/changes-v9-1-to-v10-0\" rel=\"noopener noreferrer\"><span lang=\"EN-US\">https:\/\/eacs.sanfordguide.com\/contents\/changes-v9-1-to-v10-0<\/span><\/a><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Nine short webcasts (3-5 minutes each) with each panel chair talking through the changes are online at this link:<br \/>\n<\/span><a href=\"http:\/\/resourcelibrary.eacs.cyim.com\/mediatheque\/media.aspx?mediaId=78087&amp;playlistId=78091&amp;channel=28172\" rel=\"noopener noreferrer\">http:\/\/resourcelibrary.eacs.cyim.com\/mediatheque\/media.aspx?mediaId=78087&amp;playlistId=78091&amp;channel=28172<\/a><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Translations into Chinese, French, German, Japanese, Portuguese, Russian and Spanish are currently being updated and will be available for the new edition shortly.<\/span><\/p>\n<h2 class=\"HTBBODYtext\">ART<\/h2>\n<ul>\n<li><span lang=\"EN-US\">New recommendation preferring unboosted integrase inhibitors (INSTI) with high genetic barrier (dolutegravir or bictegravir) as third drug for first-line ART.<\/span><\/li>\n<li><span lang=\"EN-US\">Doravirine + 2 NRTIs included in recommended regimens. <\/span><\/li>\n<li><span lang=\"EN-US\">When indicated, TDF\/3TC has been added as a backbone. <\/span><\/li>\n<li><span lang=\"EN-US\">Dual therapy with dolutegravir (DTG) + lamivudine (3TC) has been upgraded to recommended regimen.<\/span><\/li>\n<li><span lang=\"EN-US\">High genetic barrier INSTI or boosted PI is recommended for initial therapy if results from resistance testing are not available. <\/span><\/li>\n<li><span lang=\"EN-US\">Switch strategies for virologically suppressed persons include DTG + 3TC has been included in dual therapies supported by large clinical trials and darunavir\/b + rilpivirine has been included as dual therapy option supported by small trials.<\/span><\/li>\n<li><span lang=\"EN-US\">Whole section related to pregnancy and conception has been updated with treatment guidance regarding different scenarios.<\/span><\/li>\n<li><span lang=\"EN-US\">ART in TB\/HIV co-infection updated for new drug interactions.<\/span><\/li>\n<li><span lang=\"EN-US\">Drugs for use in PEP has been expanded to include recently approved drugs.<\/span><\/li>\n<li><span lang=\"EN-US\">F\/TAF is<\/span><span lang=\"EN-US\"> included as alternative for PrEP in MSM and transgender women.<\/span><\/li>\n<\/ul>\n<h2 class=\"HTBBODYtext\">Drug interactions<\/h2>\n<ul>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">All tables have been updated for bictegravir and doravirine and removal of older ARVs.<\/span><\/li>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">H<\/span>ormone therapy and gender transitioning.<\/li>\n<li class=\"HTBBODYtext\">Dose adjustments for non-HIV meds and kidney function.<\/li>\n<li class=\"HTBBODYtext\">Drugs classes to avoid in older people.<\/li>\n<\/ul>\n<h2 class=\"HTBBODYtext\">Comorbidities<\/h2>\n<p>This section included the greatest number of changes and new additions, covering a wide range of complications, many linked to lifestyle differences and changes.<\/p>\n<ul>\n<li class=\"HTBBODYtext\">These included use of e-cigarettes, closer cardiovascular monitoring (based on 10% rather than 20% risk), blood pressure and hypertension, renal monitoring and liver monitoring etc.<\/li>\n<li class=\"HTBBODYtext\">Sexual health changes include new statement on U=U, conception and screening for menopause.<\/li>\n<li class=\"HTBBODYtext\">T<span lang=\"EN-US\">he section on depression, include the impact on overall well-being.<\/span><\/li>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">The cognitive guidelines include either CSF resistance testing or on likely ART toxicity for modification of ART.<\/span><\/li>\n<li class=\"HTBBODYtext\">Viral hepatitis coinfection<\/li>\n<\/ul>\n<p class=\"HTBBODYtext\">Reorganised into general management, HBV and HCV with updates for:<\/p>\n<ul>\n<li class=\"HTBBODYtext\">Recommendations for screening for HCC.<\/li>\n<li class=\"HTBBODYtext\">Diagnosing fibrosis.<\/li>\n<li class=\"HTBBODYtext\">HBV reactivation.<\/li>\n<li class=\"HTBBODYtext\">Retreatment after failure with DAAs.<\/li>\n<li class=\"HTBBODYtext\">Preferred and alternative DAA combinations.<\/li>\n<li class=\"HTBBODYtext\">Management of acute HCV.<\/li>\n<li class=\"HTBBODYtext\">Management of hepatitis D and E (HDV and HEV).<\/li>\n<\/ul>\n<h2 class=\"HTBBODYtext\">Opportunistic infections (OIs)<\/h2>\n<ul>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">Updated information of timing of ART with different OIs<\/span><\/li>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">New table on clinical presentation of IRIS.<\/span><\/li>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">Updated information on treatment of CMV, HSV, VZV, histoplasmosis and cryptococcosis.<\/span><\/li>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">New information on treatment for talaromycosis.<\/span><\/li>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">Details on management of MDR-TB have been added to the TB section as well as a \u00a0table detailing doses for all TB drugs.<\/span><\/li>\n<\/ul>\n<p class=\"HTBBODYtext\"><i><span lang=\"EN-US\">Simon Collins is a community representative on the comorbidities panel for these guidelines.<\/span><\/i><\/p>\n<h3 align=\"left\">comment<\/h3>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\">These guidelines are an essential reference for the minimum standards of care that HIV positive people can use with their doctors.<\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\">They set a goal for optimum standards of care for activists when national guidelines, for example, still use older and less effective treatments.<\/span><\/strong><\/p>\n<p><strong>They also provide up-to-date guidelines for many settings when national guidelines for whatever reason are either difficult to produce or update.<\/strong><\/p>\n<p class=\"HTBBODYtext\" align=\"left\">Reference<\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">European AIDS Clinical Society (EACS). Guidelines version 10.0, November 2019.<br \/>\n<a href=\"https:\/\/www.eacsociety.org\/guidelines\/eacs-guidelines\/eacs-guidelines.html\" rel=\"noopener noreferrer\">https:\/\/www.eacsociety.org\/guidelines\/eacs-guidelines\/eacs-guidelines.html<\/a><\/span><\/p>\n<p class=\"HTBBODYtext\" align=\"left\">\n<\/p>","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Every two years EACS publish a major update to their clinical guidelines, with minor revisions on alternate years. This is an international collaboration by over 60 leading European HIV doctors with additional input from experts in &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,23],"tags":[276],"class_list":["post-36844","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-guidelines","tag-eacs-17-basel-2019"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/36844","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=36844"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/36844\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=36844"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=36844"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=36844"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}