{"id":37338,"date":"2020-03-12T08:43:09","date_gmt":"2020-03-12T08:43:09","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=37338"},"modified":"2020-05-15T10:19:05","modified_gmt":"2020-05-15T10:19:05","slug":"croi-2020-special-session-on-covid-19","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/37338","title":{"rendered":"CROI 2020: Special session on COVID-19"},"content":{"rendered":"<p class=\"HTBsubhead3authorcredit\"><strong><span lang=\"EN-US\"><img loading=\"lazy\" decoding=\"async\" class=\"alignright size-medium wp-image-37285\" src=\"https:\/\/i-base.info\/htb\/wp-content\/uploads\/2020\/03\/CROI-2020-logo-text-218x300.png\" alt=\"\" width=\"218\" height=\"300\" srcset=\"https:\/\/i-base.info\/htb\/wp-content\/uploads\/2020\/03\/CROI-2020-logo-text-218x300.png 218w, https:\/\/i-base.info\/htb\/wp-content\/uploads\/2020\/03\/CROI-2020-logo-text.png 402w\" sizes=\"auto, (max-width: 218px) 100vw, 218px\" \/>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><strong>The special session on coronavirus at CROI yesterday is posted for <a href=\"https:\/\/special.croi.capitalreach.com\" rel=\"noopener noreferrer\">open-access on the CROI website<\/a>. [1]<\/strong><\/p>\n<p class=\"HTBBODYtext\">The 75-minute overview includes four talks and a Q&amp;A at the end.<\/p>\n<p class=\"HTBBODYtext\">A few selected key points include:<\/p>\n<ul>\n<li class=\"HTBBODYtext\">The highest risk of more serious illness and outcomes (risk of dying) are older age (80&gt;70&gt;60 years old), and having other health conditions (heart, lung\/breathing, diabetes, cancer). The risk of the most serious outcomes is 5 to 30 times higher than with seasonal influenza (&#8216;flu&#8217;).<\/li>\n<li class=\"HTBBODYtext\">Implications for people living with HIV are not currently known, other than as for the general population. One speaker\u00a0included low CD4 as a possible caution. [Note: Due to lack of evidence so far a low CD4 count has not been included as a risk in the recent UK (BHIVA) statement]. [2]<\/li>\n<li class=\"HTBBODYtext\">Transmission is largely from microdroplets in air from someone during the infectious period (generally from 1 day before symptoms to average 5 days, but up to 14 days after). These can remain infectious on hard surfaces for an unknown time (possibly hours) which is why hand-washing and not touching your face is important.<\/li>\n<li class=\"HTBBODYtext\">Best ways to minimise risk of infection include washing your hands more carefully and frequently and not touching your face.<\/li>\n<li class=\"HTBBODYtext\">Soap and water is better than hand sanitisers (and more readily available).<\/li>\n<li class=\"HTBBODYtext\">Best candidate treatment (so far) is remdesivir (a Gilead compound). This has good activity against a range of viruses in in-vitro studies and is already\u00a0in at least four large randomised studies.<\/li>\n<li class=\"HTBBODYtext\">Studies with candidate vaccines are expected shortly &#8211; within two months of the virus being isolated &#8211; fastest time for vaccine development.<\/li>\n<li class=\"HTBBODYtext\">The response in China after the first cases were reported was probably much faster than it would have been in the UK. This included:<br \/>\n\u2013 \u00a0Within four days of the first reported cases, the suspect source was identified and closed (a seafood market).<br \/>\n\u2013 \u00a0Within a week, the new virus was identified (SARS-CoV-2).<br \/>\n\u2013 \u00a0The viral sequence was then shared with WHO and on databases in the public domain for other global scientists to use.<br \/>\n\u2013 \u00a0Within three weeks of the first confirmed cases, Wuhan and 15 other large cities in China were shut down (as part of a programme of containment measures).<\/li>\n<li class=\"HTBBODYtext\">One of the questions after the main talks asked whether\u00a0SARS was now extinct. The answer\u00a0explained that SARS is a bat virus, and only 50 out of about 1300 species of bats have been studied so far. So SARS is very likely still around.<\/li>\n<\/ul>\n<h3>comment<\/h3>\n<p><strong>Currently, the most important things for people living with HIV are:<\/strong><\/p>\n<ol>\n<li><strong>To make sure people have enough medications \u2013 including at least one month spare. If travelling where there might be a risk of quarantine, to take additional meds with you to cover this.<\/strong><\/li>\n<li><strong>As recommended by BHIVA, sensible hygiene precautions (hand washing and not touching your face etc). [2]<\/strong><\/li>\n<li><strong>Avoid or delay any non-essential or non-urgent hospital visits.<\/strong><\/li>\n<li><strong>Special caution for those who are older or who have multimorbidities &#8211; and these are especially prevalent in HIV.<\/strong><\/li>\n<\/ol>\n<p class=\"HTBBODYtext\">References<\/p>\n<ol>\n<li class=\"HTBBODYtext\"><span lang=\"EN-US\">Special session on COVID-19. CROI 2020, 8\u201311 March 2020.<br \/>\n<\/span><a href=\"https:\/\/special.croi.capitalreach.com\" rel=\"noopener noreferrer\"><span lang=\"EN-US\">https:\/\/special.croi.capitalreach.com<\/span><\/a><\/li>\n<li class=\"HTBBODYtext\">BHIVA. Comment on COVID-19 from the British HIV Association. 27 February 2020.<br \/>\n<a href=\"https:\/\/www.bhiva.org\/comment-on-COVID-19-from-BHIVA\" rel=\"noopener noreferrer\">https:\/\/www.bhiva.org\/comment-on-COVID-19-from-BHIVA<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base The special session on coronavirus at CROI yesterday is posted for open-access on the CROI website. [1] The 75-minute overview includes four talks and a Q&amp;A at the end. A few selected key points include: The &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,43,290,287],"tags":[277],"class_list":["post-37338","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-virology","category-covid-19-pathogenesis","category-covid-19-on-the-web","tag-croi-2020"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37338","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=37338"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37338\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=37338"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=37338"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=37338"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}