{"id":37617,"date":"2020-04-17T07:43:24","date_gmt":"2020-04-17T07:43:24","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=37617"},"modified":"2020-05-15T09:52:54","modified_gmt":"2020-05-15T09:52:54","slug":"evidence-review-for-repurposed-compounds-idsa-guidelines-for-covid-19","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/37617","title":{"rendered":"Evidence review for treatment: IDSA guidelines for COVID-19"},"content":{"rendered":"<p class=\"HTBBODYtext\"><b><strong><span lang=\"EN-US\"><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/><\/span><\/strong>Simon Collins, HIV i-Base<\/b><\/p>\n<p class=\"HTBBODYtext\"><b>On 11 April 2020, the Infectious Diseases Society of America (ISDA) published a very clear evidence review of the main compounds being studied for the management COVID-19. [1]<\/b><\/p>\n<p class=\"HTBBODYtext\">This document is planned in three parts. This section deals with treatment and management. Part two on diagnostics and part three on prevention are due to be published shortly.<\/p>\n<p class=\"HTBBODYtext\">The guideline lists five investigational treatments of repurposed drugs for people who are hospitalised with COVID-19, all in the context of a clinical trial.<\/p>\n<p class=\"HTBBODYindent\"><span lang=\"EN-US\">\u2022\u00a0\u00a0 Hydroxychloroquine\/chloroquine.<\/span><\/p>\n<p class=\"HTBBODYindent\"><span lang=\"EN-US\">\u2022\u00a0\u00a0 Hydroxychloroquine\/chloroquine plus azithromycin.<\/span><\/p>\n<p class=\"HTBBODYindent\"><span lang=\"EN-US\">\u2022\u00a0\u00a0 Lopinavir\/ritonavir.<\/span><\/p>\n<p class=\"HTBBODYindent\"><span lang=\"EN-US\">\u2022\u00a0\u00a0 Tocilizumab<\/span><\/p>\n<p class=\"HTBBODYindent\"><span lang=\"EN-US\">\u2022\u00a0\u00a0 Convalescent plasma<\/span><\/p>\n<p class=\"HTBBODYtext\">Corticosteroids are not recommended in patients with COVID-19 pneumonia but are an option for COVID-19 that presents with other symptoms.<\/p>\n<p class=\"HTBBODYtext\">The detailed evidence review for each of these approaches is less than optimistic: none shows strong evidence for benefit and all include evidence of risk.<\/p>\n<p class=\"HTBBODYtext\">Additional compounds are also discussed.<\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">References<\/span><\/p>\n<ol>\n<li class=\"HTBreferences\"><span lang=\"EN-US\">Bhimrai A et al. Infectious Diseases Society of America guidelines on the treatment and management of patients with COVID-19. (11 April 2020).<br \/>\n<\/span><a href=\"https:\/\/www.idsociety.org\/practice-guideline\/covid-19-guideline-treatment-and-management\" rel=\"noopener noreferrer\">https:\/\/www.idsociety.org\/practice-guideline\/covid-19-guideline-treatment-and-management<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base On 11 April 2020, the Infectious Diseases Society of America (ISDA) published a very clear evidence review of the main compounds being studied for the management COVID-19. [1] This document is planned in three parts. This &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[285,278],"tags":[],"class_list":["post-37617","post","type-post","status-publish","format-standard","hentry","category-covid-19-guidelines","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37617","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=37617"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37617\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=37617"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=37617"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=37617"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}