{"id":37625,"date":"2020-04-17T07:35:49","date_gmt":"2020-04-17T07:35:49","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=37625"},"modified":"2020-05-15T10:06:13","modified_gmt":"2020-05-15T10:06:13","slug":"covid-19-prophylaxis-using-tdf-ftc-and-low-dose-hydrochloroquine-in-spanish-health-workers","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/37625","title":{"rendered":"COVID-19 prophylaxis using TDF\/FTC and low-dose hydroxychloroquine in Spanish health workers"},"content":{"rendered":"<p class=\"HTBsubhead3authorcredit\"><strong><span lang=\"EN-US\"><b><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/><\/b>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\">A large randomised phase 3 placebo-controlled study in Spain is using the HIV PrEP combination TDF\/FTC and low-dose hydroxychloroquine (HCQ) as prophylaxis for COVID-19 in health workers. [1]<\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Although in-vitro data support potential antiviral activity of TDF\/FTC against CoV-2, the rationale was also driven by anecdotal reports of fewer cases of severe COVID-19 in Spain in HIV positive people on ART.<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">The study plans to enroll 4000 participants who will be randomised to one of three active arms or an inactive placebo group. The active arms are TDF\/FTC, <\/span>hydroxychloroquine (200 mg daily) and a dual combination of TDF\/FTC plus HCQ.<\/p>\n<p class=\"HTBBODYtext\">The study is due to start in April 2020 and will run until July.<\/p>\n<h3><b>comment<\/b><\/h3>\n<p><b>The decision to investigate TDF\/FTC for PrEP does not mean that there this will be effective.<span class=\"Apple-converted-space\">\u00a0<\/span><\/b><\/p>\n<p><b>Also, some HIV positive people have been diagnosed with COVID-19, even though they are taking TDF\/TFC-containing ART.<\/b><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Reference<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">clinicaltrials.gov. Randomized clinical trial for the prevention of SARS-CoV-2 infection (COVID-19) in healthcare personnel (EPICOS).<br \/>\n<\/span><a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT04334928\" rel=\"noopener noreferrer\"><span lang=\"EN-US\">https:\/\/clinicaltrials.gov\/ct2\/show\/study\/NCT04334928<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base A large randomised phase 3 placebo-controlled study in Spain is using the HIV PrEP combination TDF\/FTC and low-dose hydroxychloroquine (HCQ) as prophylaxis for COVID-19 in health workers. [1] Although in-vitro data support potential antiviral activity of &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[289,288,278],"tags":[],"class_list":["post-37625","post","type-post","status-publish","format-standard","hentry","category-covid-19-transmission","category-covid-19-research-studies","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37625","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=37625"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37625\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=37625"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=37625"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=37625"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}