{"id":37627,"date":"2020-04-17T07:32:09","date_gmt":"2020-04-17T07:32:09","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=37627"},"modified":"2020-05-15T10:37:30","modified_gmt":"2020-05-15T10:37:30","slug":"a-clinical-therapeutic-staging-proposal-for-covid-19","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/37627","title":{"rendered":"A clinical-therapeutic staging proposal for COVID-19"},"content":{"rendered":"

<\/b>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n

This short paper proposes a three-stage classification for COVID-19, with increasing severity that corresponds with distinct clinical findings, responses to therapy and clinical outcomes.<\/span><\/strong><\/p>\n

Stage I (mild) \u2013 early infection<\/span><\/h3>\n

The initial stage occurs at the time of inoculation and early establishment of disease. For most people, this involves an incubation period associated with mild and often non-specific symptoms such as malaise, fever and a dry cough. <\/span><\/p>\n

Stage II (moderate) – pulmonary involvement (IIa) without and (IIb) with hypoxia: <\/span><\/h3>\n

In the second stage of established pulmonary disease, viral multiplication and localised inflammation in the lung is the norm. During this stage, patients develop a viral pneumonia, with cough, fever and possibly hypoxia (defined as a PaO2\/FiO2 of <300 mmHg). <\/span><\/p>\n

Stage III (severe) \u2013 systemic hyperinflammation: <\/span><\/h3>\n

A minority of COVID-19 patients will transition into the third and most severe stage of illness, which manifests as an extra-pulmonary systemic hyperinflammation syndrome. In this stage, markers of systemic inflammation appear to be elevated. COVID-19 infection results in a decrease in helper, suppressor and regulatory T cell counts. <\/span><\/p>\n

References<\/span><\/p>\n

Siddiqi HK et al. A clinical-therapeutic staging proposal COVID-19 illness in native and immunosuppressed states: a clinical-therapeutic staging proposal. Journal of Heart and Lung Transplant. DOI: 10.1016\/j.healun.2020.03.012
\n<\/span>https:\/\/www.jhltonline.org\/article\/S1053-2498(20)31473-X\/fulltext<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base This short paper proposes a three-stage classification for COVID-19, with increasing severity that corresponds with distinct clinical findings, responses to therapy and clinical outcomes. Stage I (mild) \u2013 early infection The initial stage occurs at the …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[290,278],"tags":[],"class_list":["post-37627","post","type-post","status-publish","format-standard","hentry","category-covid-19-pathogenesis","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37627","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=37627"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37627\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=37627"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=37627"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=37627"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}