{"id":37830,"date":"2020-05-14T08:41:54","date_gmt":"2020-05-14T08:41:54","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=37830"},"modified":"2020-05-15T02:55:04","modified_gmt":"2020-05-15T02:55:04","slug":"case-studies-show-darunavir-does-not-protect-against-cov-2","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/37830","title":{"rendered":"Case-studies show darunavir does not protect against CoV-2"},"content":{"rendered":"<p class=\"HTBsubhead3authorcredit\"><strong><span lang=\"EN-US\"><b><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/><\/b>Simon Collins, HIV i-Base <\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\">Although in vitro studies reported possible antiviral activity of boosted darunavir (DRV) against CoV-2, in March 2020 Janssen issued an early statement advising against using this drug in research against COVID 19. [1]<\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Nevertheless, and to confirm lack of protection, three cases have been reported of HIV positive people (two men and one woman) who were diagnosed with COVID-19 despite using boosted-darunavir-based ART. [2]<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">The historical details of the three cases are not worth reporting, as the approach to management is already out of date and against current guidelines (ie &#8211; switching DRV to lopinavir\/r and adding hydroxychloroquine).<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">References<\/span><\/p>\n<ol>\n<li class=\"HTBreferences\"><span lang=\"EN-US\">Janssen press statement. Lack of evidence to support use of darunavir-based treatments for SARS-CoV-2. (16 March 2020).<br \/>\n<\/span><a href=\"https:\/\/www.janssen.com\/uk\/sars-cov-2-treatment\" rel=\"noopener noreferrer\"><span lang=\"EN-US\">https:\/\/www.janssen.com\/uk\/sars-cov-2-treatment<\/span><\/a><\/li>\n<li class=\"HTBreferences\"><span lang=\"EN-US\">Riva D et al. Darunavir does not prevent SARS-CoV-2 infection in HIV patients. Pharmacological Research (157), 104826 (20 April 2020).<br \/>\n<\/span><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820311348\" rel=\"noopener noreferrer\"><span lang=\"EN-US\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1043661820311348<\/span><\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Although in vitro studies reported possible antiviral activity of boosted darunavir (DRV) against CoV-2, in March 2020 Janssen issued an early statement advising against using this drug in research against COVID 19. [1] Nevertheless, and to &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[282,278],"tags":[],"class_list":["post-37830","post","type-post","status-publish","format-standard","hentry","category-covid-19-hiv-and-covid-19-coinfection","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37830","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=37830"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37830\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=37830"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=37830"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=37830"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}