{"id":37903,"date":"2020-05-14T08:22:21","date_gmt":"2020-05-14T08:22:21","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=37903"},"modified":"2020-05-15T13:00:42","modified_gmt":"2020-05-15T13:00:42","slug":"covid-19-pathogenisis-potential-for-cov-2-to-be-widely-distributed-in-the-body","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/37903","title":{"rendered":"Potential for CoV-2 to be widely distributed in cells throughout the body"},"content":{"rendered":"<p class=\"HTBsubhead3authorcredit\"><strong><span lang=\"EN-US\"><b><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/><\/b>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><strong>These two papers are based on analyses from single-cell sequencing datasets and support the idea that COVID-19 is not just a respiratory disease but an illness that can affect multiple organs.<\/strong><\/p>\n<p class=\"HTBBODYtext\">The links are to a preprint article published on bioRxiv on 21 April 2020 and a related review that <span lang=\"EN-US\">shows that other potential target cells also producing ACE2 and TMPRSS2 are common throughout the body \u2013 including in the heart, bladder, pancreas, kidney, nose, eyes and brain. <\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Many are epithelial cells lining the outer surface of organs and the new findings add to an emerging picture of SARS-CoV-2 as a virus that can target cells in many places in the human body, rather than being focused on a particular organ or part of the respiratory tract.\u00a0<\/span><\/p>\n<p class=\"HTBBODYtext\"><b>Receptors for SARS-CoV-2 present in wide variety of human cells.<\/b><\/p>\n<p class=\"HTBBODYtext\">Baraniuk C. <span lang=\"EN-US\">Science. (29 Apr 2020).<\/span><\/p>\n<p class=\"HTBBODYtext\"><a href=\"https:\/\/www.the-scientist.com\/news-opinion\/receptors-for-sars-cov-2-present-in-wide-variety-of-human-cells-67496\" rel=\"noopener noreferrer\"><span lang=\"EN-US\">https:\/\/www.the-scientist.com\/news-opinion\/receptors-for-sars-cov-2-present-in-wide-variety-of-human-cells-67496<\/span><\/a><\/p>\n<p class=\"HTBBODYtext\"><b><span lang=\"EN-US\">Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells. <\/span><\/b><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Muus C et al. DOI: 10.1101\/2020.04.19.049254. (21 April 2020).<\/span><\/p>\n<p class=\"HTBBODYtext\"><a href=\"https:\/\/www.biorxiv.org\/content\/10.1101\/2020.04.19.049254v2\" rel=\"noopener noreferrer\"><span lang=\"EN-US\">https:\/\/www.biorxiv.org\/content\/10.1101\/2020.04.19.049254v2<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base These two papers are based on analyses from single-cell sequencing datasets and support the idea that COVID-19 is not just a respiratory disease but an illness that can affect multiple organs. The links are to a &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[290,287,278],"tags":[],"class_list":["post-37903","post","type-post","status-publish","format-standard","hentry","category-covid-19-pathogenesis","category-covid-19-on-the-web","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37903","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=37903"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37903\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=37903"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=37903"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=37903"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}