{"id":37905,"date":"2020-05-14T08:21:19","date_gmt":"2020-05-14T08:21:19","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=37905"},"modified":"2020-05-15T16:24:05","modified_gmt":"2020-05-15T16:24:05","slug":"debate-over-development-of-pathogenic-strains-of-cov-2-2","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/37905","title":{"rendered":"Debate over development of pathogenic strains of CoV-2"},"content":{"rendered":"

<\/b>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n

In the last couple of weeks different research groups have presented various analyses on whether or not CoV-2 mutated into a more pathogenic and easier to transmit form.<\/span><\/strong><\/p>\n

Related articles are included below.<\/span><\/p>\n

Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2.<\/strong>
\nKorber B al. bioRxiv.\u00a0doi:\u00a010.1101\/2020.04.29.069054
\nhttps:\/\/www.biorxiv.org\/content\/10.1101\/2020.04.29.069054v2<\/a>
\n<\/span><\/p>\n

This\u00a033-page report raises concerns that the virus has mutated into a more severe from. Although from established researchers (with a history of HIV-related research), it is a\u00a0bioRxiv\u00a0preprint that has not been peer reviewed.<\/span><\/p>\n

SARS-CoV-2 viral spike G614 mutation exhibits higher case fatality rate<\/b><\/p>\n

Manuel Becerra-Flores and Timothy Cardozo, Int J Clin Pract.\u00a02020\u00a0May 6. doi: 10.1111\/ijcp.13525.
\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/32374903<\/a><\/p>\n

This study from NYU supports the more pathogenic mutation from Korber et al.<\/p>\n

The problem with stories about dangerous coronavirus mutations.
\n<\/span><\/b>Yong E. The Atlantic.
\n<\/span>https:\/\/www.theatlantic.com\/health\/archive\/2020\/05\/coronavirus-strains-transmissible\/611239<\/span><\/a>
\nA new report that is critical of the findings.<\/span><\/p>\n

Details discussed in Twitter thread
\n<\/span><\/b>Trevor Bedford \u00a0(from Fred Hutchinson\/<\/span>https:\/\/nextstrain.org\/<\/a><\/span>).<\/span>
\n<\/span><\/b>https:\/\/twitter.com\/trvrb\/status\/1257825352660877313<\/span><\/a><\/p>\n

Some coronaviruses can reinfect the same person quickly:\u00a0will that happen with SARS-CoV-2?
\n<\/span><\/b>Mark Mascolini report for NATAP.org
\n<\/span>http:\/\/natap.org\/2020\/COVID\/043020_04.htm<\/span><\/a><\/p>\n

Study finds nearly everyone who recovers from COVID-19 makes coronavirus antibodies.
\n<\/span><\/b>Francis Collins, NIH Directors Blog.
\n<\/span>https:\/\/directorsblog.nih.gov\/2020\/05\/07\/study-finds-nearly-everyone-who-recovers-from-covid-19-makes-coronavirus-antibodies<\/span><\/a><\/p>\n

Antibody responses to SARS-CoV-2 in patients with COVID-19.
\n<\/span><\/b>Long QX et al. Nat Med. (29 April 2020).
\n<\/span>https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/32350462<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base In the last couple of weeks different research groups have presented various analyses on whether or not CoV-2 mutated into a more pathogenic and easier to transmit form. Related articles are included below. Spike mutation pipeline …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[290,287,278],"tags":[],"class_list":["post-37905","post","type-post","status-publish","format-standard","hentry","category-covid-19-pathogenesis","category-covid-19-on-the-web","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=37905"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/37905\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=37905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=37905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=37905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}