{"id":38076,"date":"2020-06-01T07:31:24","date_gmt":"2020-06-01T07:31:24","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=38076"},"modified":"2020-06-01T15:57:09","modified_gmt":"2020-06-01T15:57:09","slug":"tocilizumab-and-remdesivir-in-new-dual-therapy-study","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/38076","title":{"rendered":"Tocilizumab and remdesivir in new dual therapy study"},"content":{"rendered":"<p class=\"HTBsubhead3authorcredit\"><strong><span lang=\"EN-US\"><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n<p class=\"HTBBODYFIRST\"><strong><span lang=\"EN-US\">As dual and triple combination therapy becomes an important approach for COVID-19 a new randomised phase 3 study a new study has been announced that will use tocilizumab plus remdesivir with a control arm using remdesivir alone. [1]<\/span><\/strong><\/p>\n<p class=\"HTBBODYFIRST\"><span lang=\"EN-US\">The study (called <\/span>REMDACTA)<span lang=\"EN-US\">\u00a0is not yet listed on clinicaltrials.gov.\u00a0<\/span><\/p>\n<p class=\"HTBBODYtext\">It is supported by Roche and Gilead (manufacturers of tocilizumab and remdesivir, resptectively) and is expected to begin enrol 450 participants globally from June 2020.<\/p>\n<p class=\"HTBBODYtext\">More than 40 studies of tocilizumab are listed on clincaltrials.gov registry as either ongoing or planned. This includes the large multi-arm UK RECOVERY study that has already enrolled more than 10,500 participants. [2]<\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">References<\/span><\/p>\n<ol>\n<li class=\"HTBBODYtext\">Roche press release. Roche initiates phase III clinical trial of Actemra\/RoActemra plus remdesivir in hospitalised patients with severe COVID-19 pneumonia. (28 May 2020).<br \/>\n<a href=\"https:\/\/www.roche.com\/media\/releases\/med-cor-2020-05-28.htm\" rel=\"noopener noreferrer\">https:\/\/www.roche.com\/media\/releases\/med-cor-2020-05-28.htm<\/a><\/li>\n<li class=\"HTBBODYtext\">clinicaltrials.gov. Randomized evaluation of\u00a0COVID-19\u00a0therapy (RECOVERY). NCT04381936.<br \/>\n<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04381936\" rel=\"noopener noreferrer\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04381936<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base As dual and triple combination therapy becomes an important approach for COVID-19 a new randomised phase 3 study a new study has been announced that will use tocilizumab plus remdesivir with a control arm using remdesivir &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[283,288,278],"tags":[],"class_list":["post-38076","post","type-post","status-publish","format-standard","hentry","category-covid-19-investigational-drugs","category-covid-19-research-studies","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=38076"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38076\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=38076"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=38076"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=38076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}