{"id":38292,"date":"2020-06-26T07:21:39","date_gmt":"2020-06-26T07:21:39","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=38292"},"modified":"2020-06-26T12:22:38","modified_gmt":"2020-06-26T12:22:38","slug":"two-pep-studies-report-no-benefit-of-hydroxchloroquine-for-preventing-cov-2-infection","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/38292","title":{"rendered":"Two PEP studies report no benefit of hydroxychloroquine for preventing CoV-2 infection"},"content":{"rendered":"

Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n

Two studies reported lack of benefit from using hydroxychloroquine (HCQ) as PEP.<\/span><\/strong><\/p>\n

One was <\/span>a randomised, double-blind, placebo-controlled trial in 821 participants reporting high-risk exposure and who started HCQ PEP within three days. Results reported no difference in COVID-19 between the two arms and were published in the NEJM. [1]<\/span><\/p>\n

COVID-19 was confirmed in 49\/414 (11.8%) vs 58\/407 (14.3%) of active vs placebo arms: diff \u22122.4% (95% CI: \u22127.0 to 2.2),\u00a0 p=0.35.<\/span><\/p>\n

The second was a Spanish study that <\/span>randomised more than 2300 people exposed to the CoV-2 to either HCQ or the usual care.\u00a0Although not yet published, the top-line results of no difference between the two arms was reported in Science journal online. [2, 3]<\/span><\/p>\n

References<\/span><\/p>\n

    \n
  1. Boulware \u00a0DR et al. A randomized trial of hydroxychloroquine as postexposure prophylaxis for COVID-19. NEJM. DOI: 10.1056\/NEJMoa2016638. (3 June 2020).
    \nhttps:\/\/www.nejm.org\/doi\/full\/10.1056\/NEJMoa2016638<\/a><\/li>\n
  2. clinicaltrials.gov. Treatment of COVID-19 Cases and Chemoprophylaxis of Contacts as Prevention (HCQ4COV19).
    \n<\/b>    https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04304053<\/a><\/li>\n
  3. Kupferschmidt K. Three big studies dim hopes that hydroxychloroquine can treat or prevent COVID-19. Science. \u00a0(9 June 2020)
    \n    https:\/\/www.sciencemag.org\/news\/2020\/06\/three-big-studies-dim-hopes-hydroxychloroquine-can-treat-or-prevent-covid-19<\/span><\/a><\/li>\n<\/ol>\n

    \n<\/p>","protected":false},"excerpt":{"rendered":"

    Simon Collins, HIV i-Base Two studies reported lack of benefit from using hydroxychloroquine (HCQ) as PEP. One was a randomised, double-blind, placebo-controlled trial in 821 participants reporting high-risk exposure and who started HCQ PEP within three days. Results reported no …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[289,278],"tags":[],"class_list":["post-38292","post","type-post","status-publish","format-standard","hentry","category-covid-19-transmission","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38292","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=38292"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38292\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=38292"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=38292"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=38292"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}