{"id":38365,"date":"2020-07-22T07:24:47","date_gmt":"2020-07-22T07:24:47","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=38365"},"modified":"2020-07-23T17:52:00","modified_gmt":"2020-07-23T17:52:00","slug":"hydroxychloroquine-and-lopinavir-r-arms-stopped-in-the-who-solidarity-study","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/38365","title":{"rendered":"Hydroxychloroquine and lopinavir\/r arms stopped in the WHO SOLIDARITY study"},"content":{"rendered":"

<\/b>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n

On 4 July, the WHO announced that two experimental arms of the international SOLIDARITY study \u2013 using hydroxychloroquine and lopinavir\/r \u2013 were now stopped based on results from an interim analysis. [1]<\/span><\/strong><\/p>\n

The decision was also based on results from other studies that was <\/span>presented at the WHO Summit on COVID-19 research and innovation from 1-2 July 2020. This would have included similar results that were recently announced from the UK RECOVERY study.<\/span><\/p>\n

The press release is not very clear on other aspects of the study and provides no further details of the results, other than that these will be published later.\u00a0<\/span><\/p>\n

As of 1 July 2020, nearly 5500 patients have been recruited in SOLIDARITY from 21 of the 39 countries that have approval to begin recruiting.<\/span>\u00a0[2]<\/p>\n

The remaining two arms in SOLIDARITY are remdesivir and a dual combination of lopinavir\/r plus interferon beta-1a. It is unclear whether lopinavir\/r will also be discontinued in this second arm.<\/p>\n

COMMENT<\/strong><\/p>\n

It is important that ongoing studies promptly respond to new evidence that becomes available on both the investigational interventions and the management of COVID-19 in general.<\/strong><\/p>\n

These negative results should also prompt closer review of studies where DSMB access to unblinded data is not showing any clear signal of efficacy.<\/strong><\/p>\n

Reference<\/span><\/p>\n

    \n
  1. WHO. WHO discontinues hydroxychloroquine and lopinavir\/ritonavir treatment arms for COVID-19. (4 July 2020).
    \n<\/span>https:\/\/www.who.int\/news-room\/detail\/04-07-2020-who-discontinues-hydroxychloroquine-and-lopinavir-ritonavir-treatment-arms-for-covid-19<\/a><\/li>\n
  2. WHO SOLIDARITY Study.
    \n    https:\/\/www.who.int\/emergencies\/diseases\/novel-coronavirus-2019\/global-research-on-novel-coronavirus-2019-ncov\/solidarity-clinical-trial-for-covid-19-treatments<\/a><\/li>\n<\/ol>\n

    This report was first published on 5 July 2020.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

    Simon Collins, HIV i-Base On 4 July, the WHO announced that two experimental arms of the international SOLIDARITY study \u2013 using hydroxychloroquine and lopinavir\/r \u2013 were now stopped based on results from an interim analysis. [1] The decision was also …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[283,278],"tags":[],"class_list":["post-38365","post","type-post","status-publish","format-standard","hentry","category-covid-19-investigational-drugs","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38365","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=38365"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38365\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=38365"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=38365"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=38365"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}