{"id":38445,"date":"2020-07-22T07:20:40","date_gmt":"2020-07-22T07:20:40","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=38445"},"modified":"2020-07-23T18:02:57","modified_gmt":"2020-07-23T18:02:57","slug":"uk-study-reports-antibody-responses-linked-to-more-severe-covid-19-in-higher-risk-populations","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/38445","title":{"rendered":"UK study reports antibody responses linked to more severe COVID-19 in higher risk populations"},"content":{"rendered":"<p class=\"HTBsubhead3authorcredit\"><strong><span lang=\"EN-US\"><b><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/><\/b>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\">UK longitudinal study reports seroconversion dynamics by IgG ELISA from 845 samples from 177 adults previously diagnosed with SARS-CoV-2 by RT-PCR. <\/span><\/strong><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Baseline characteristics included <\/span>34% white, 35% non-white, median (IQR) age 64 years (IQR: 52 to 77), 57% male, and 73% had one or more co-morbidities; 19% were defined as asymptomatic with no respiratory symptoms on admission.<\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Seroconversion was associated with older age, more comorbidities (especially hypertension and higher BMI), non-white race and higher inflammatory markers (CRP), but 8.5% of participants showed no evidence of seroconversion even weeks after infection.<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Antibody responses were maintained for more than two months.<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Overall, 25% (44\/177) died after median (IQR) 19.1 days (14.8 to 24.8).<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">The paper concluded that longer studies are needed to find out the duration of humoral responses that contribute to protection against future SARS-CoV-2 exposures.<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Reference<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Staines HM et al. <\/span>Dynamics of IgG seroconversion and pathophysiology of COVID-19 infections. MedRxiv. Pre-peer review paper. DOI: 10.1101\/2020.06.07.20124636. (8 June 2020).<br \/>\n<a href=\"https:\/\/www.medrxiv.org\/content\/10.1101\/2020.06.07.20124636v2\" rel=\"noopener noreferrer\">https:\/\/www.medrxiv.org\/content\/10.1101\/2020.06.07.20124636v2<\/a><\/p>\n<p><em>This report was first published on 12 July 2020.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base UK longitudinal study reports seroconversion dynamics by IgG ELISA from 845 samples from 177 adults previously diagnosed with SARS-CoV-2 by RT-PCR. Baseline characteristics included 34% white, 35% non-white, median (IQR) age 64 years (IQR: 52 to &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[290,278],"tags":[],"class_list":["post-38445","post","type-post","status-publish","format-standard","hentry","category-covid-19-pathogenesis","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38445","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=38445"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38445\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=38445"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=38445"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=38445"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}