{"id":3869,"date":"2000-09-16T21:54:39","date_gmt":"2000-09-16T20:54:39","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3869"},"modified":"2014-07-01T12:10:36","modified_gmt":"2014-07-01T12:10:36","slug":"topical-cidofovir-clears-severe-molluscum-contagiosum-in-children-with-aids","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3869","title":{"rendered":"Topical cidofovir clears severe molluscum contagiosum in children with AIDS"},"content":{"rendered":"<p><strong>Topical 3% cidofovir was successful in clearing disseminated molluscum contagiosum refractory to other treatment in 2 children with AIDS, according to Dr Jorge R. Toro and colleagues from the National Cancer Institute in Bethesda, Md.<\/strong><\/p>\n<p>Previous treatments had included liquid nitrogen, cantharidin, and tretinoin gel. Both patients had been on highly active antiretroviral therapy (HAART) for a median of 24 months.<\/p>\n<p>The facial lesions were so disfiguring that the patients, an 8-year-old boy and a 4-year-old boy, experienced severe social isolation. The CD4 T-cell counts were 329 and 168 cells\/\u00b5L, with viral loads of log 5.86 and log 5.63 HIV RNA copies\/mL, respectively.<\/p>\n<p>In an interview with Reuters Health, Dr Toro pointed out that &#8220;If you&#8217;re treating patients with HAART and the viral load doesn&#8217;t go down, then you are talking about a very resistant kind of situation.&#8221;<\/p>\n<p>Cidofovir was mixed with Dermovan, a combination vehicle containing propylene glycol, and applied to lesions once a day, 5 days a week, for 8 weeks. Nonfacial and nonmucosal lesions were also occluded with adhesive tape for at least 12 hours at each application, Dr Toro told Reuters Health.<\/p>\n<p>Five to 15 days after beginning the cidofovir treatment, both boys exhibited redness and painful erosions at the sites of the previous lesions, although surrounding skin was unaffected. &#8220;After 2 months of treatment, all the lesions that were treated showed complete clinical resolution,&#8221; the investigators write.<\/p>\n<p>&#8220;The success of treatment is very dependent on the vehicle,&#8221; Dr Toro said. He explained that a commercially available preparation of 1% cidofovir uses a completely different vehicle. &#8220;For patients using that specific type, it didn&#8217;t work,&#8221; he said, adding that &#8220;It has to be compounded in this particular vehicle and it has to be fresh and it has to be kept refrigerated.<\/p>\n<p>&#8220;We saw 1 of the boys 2 weeks ago, and there&#8217;s been no recurrence of any lesions after more than 2 years,&#8221; Dr Toro said.<\/p>\n<p>Reference:<\/p>\n<p>Arch Dermatol. 2000;136:983-985.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Topical 3% cidofovir was successful in clearing disseminated molluscum contagiosum refractory to other treatment in 2 children with AIDS, according to Dr Jorge R. Toro and colleagues from the National Cancer Institute in Bethesda, Md. Previous treatments had included liquid &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32,31],"tags":[],"class_list":["post-3869","post","type-post","status-publish","format-standard","hentry","category-paediatric-care","category-opportunistic-infections-coinfections-and-complications"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3869","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3869"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3869\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3869"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3869"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3869"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}