{"id":3879,"date":"2000-09-16T22:05:04","date_gmt":"2000-09-16T22:05:04","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3879"},"modified":"2014-07-01T12:11:36","modified_gmt":"2014-07-01T12:11:36","slug":"population-of-hiv-targeted-cd8-cells-fluctuates-with-viral-load-during-chronic-infection","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3879","title":{"rendered":"Population of HIV-targeted CD8 cells fluctuates with viral load during chronic infection"},"content":{"rendered":"<p><strong>The population of HIV-specific CD8 T cells declines with extended use of effective antiretroviral therapies in infected patients. However, CD8 T cells are remobilised during viral rebound as a result of treatment interruption or failure, according to a report in the August 1st issue of the Journal of Immunology.<\/strong><\/p>\n<p>&#8220;Such dynamics of virus-specific CD8 T cells should be taken into account when elaborating future strategies of scheduled antiretroviral treatment interruptions aiming at restoring specific defenses against HIV,&#8221; Dr Brigitte Autran, of the Centre National de la Recherche Scientifique, Paris, France, and members of the RESTIM and COMET study groups, conclude.<\/p>\n<p>The researchers evaluated the association between viral load and HIV-specific CD8 cell populations in 15 chronically infected patients receiving highly active antiretroviral therapy. They were able to monitor the existence of 16 different cytotoxic T-cell epitopes in 14 of the patients.<\/p>\n<p>During the first month of treatment, viral load decreased rapidly. At the same time, the population of HIV-specific CD8 cells in the peripheral blood tripled, while 8 new HIV-specific epitopes, as well as previously undetectable cytomegalovirus-specific epitopes, appeared.<\/p>\n<p>With extended suppression of viral load, the population of HIV-specific CD8 cells in the patients declined, Dr Autran&#8217;s group found. But these cells remain capable of remobilisation, as &#8220;rebounds of HIV replication are paralleled by peaks in memory CD8 T lymphocytes that quickly restore the pre-existing host-virus quasi-equilibrium,&#8221; they write.<\/p>\n<p>Specifically, the authors observed 4 patterns of epitope-specific CD8 cell dynamics during viral rebound: &#8220;peaks or disappearance of pre-existing specificities, emergence of new specificities or lack of changes.&#8221;<\/p>\n<p>Dr Autran&#8217;s group concludes that these dynamics may have an impact on therapeutic interruption strategies aimed at increasing the host response to HIV.<\/p>\n<p>Reference:<\/p>\n<p>J Immunol. 2000;165:1692-1704.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The population of HIV-specific CD8 T cells declines with extended use of effective antiretroviral therapies in infected patients. However, CD8 T cells are remobilised during viral rebound as a result of treatment interruption or failure, according to a report in &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[15],"tags":[],"class_list":["post-3879","post","type-post","status-publish","format-standard","hentry","category-basic-science-and-immunology"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3879","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3879"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3879\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3879"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3879"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3879"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}