{"id":38849,"date":"2020-08-28T07:15:00","date_gmt":"2020-08-28T07:15:00","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=38849"},"modified":"2020-09-02T00:41:47","modified_gmt":"2020-09-02T00:41:47","slug":"hiv-organisations-oppose-active-challenge-covid-19-vaccine-studies","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/38849","title":{"rendered":"HIV organisations oppose active-challenge COVID-19 vaccine studies"},"content":{"rendered":"

<\/strong>Simon\u00a0Collins,\u00a0HIV\u00a0i-Base<\/b><\/p>\n

Numerous HIV community groups recently circulated a statement against the use of active challenge studies on COVID-19 vaccine studies. [1]<\/strong><\/p>\n

This was in response to a proposal in an open letter from a group of prominent scientists to directly expose volunteers on COVID-19 vaccine studies to SARS-CoV-2. [2] This proposal is also being considered by the Oxford Vaccine Group and had been discussed several months earlier in a paper in JID. [3, 4]<\/p>\n

For many community advocates, the lack of an effective treatment for COVID-19 makes the proposal to use active challenge unethical. Even in younger paritcipants at lower population risk, COVID-19 related fatalities would just be a factor of chance and study numbers. Serious reactions to COVID-19 are also increasingly associated with long-term complications.<\/p>\n

Also, importantly, the number of regions where incidence of COVID-19 are sufficiently high to evaluate responses to candidate vaccines. A recent letter in JID on the paper by Eyal et al discussed why challenge studies wouldn\u2019t generate faster or more effective vaccines against COVID-19 and that because outcomes from SARS-CoV-2 are not self limiting, this approach is unethical. [5]<\/p>\n

Referencs<\/p>\n

    \n
  1. AVAC and TAG. Statement on Human Challenge Studies for COVID-19 Vaccine Development. (17 July 2020).
    \nhttps:\/\/www.avac.org\/blog\/statement-human-challenge-studies-covid<\/a><\/li>\n
  2. 1DaySooner. COVID-19 Human Challenge Trials.
    \n    https:\/\/1daysooner.org\/openletter<\/a><\/li>\n
  3. Coronavirus vaccine: Oxford team aim to start lab-controlled human trials. The Guardian. (16 July 2020).
    \n    https:\/\/www.theguardian.com\/science\/2020\/jul\/16\/coronavirus-vaccine-oxford-team-volunteers-lab-controlled-human-challenge-trial<\/a><\/li>\n
  4. Eyal N et al. Human challenge studies to accelerate coronavirus vaccine licensure. JID, 221(11);1752\u20131756. DOI: 10.1093\/infdis\/jiaa152. (31 March 2020).
    \n    https:\/\/academic.oup.com\/jid\/article\/221\/11\/1752\/5814216<\/a><\/li>\n
  5. Spinola SM et al. Human challenge studies are unlikely to accelerate coronavirus vaccine licensure due to ethical and practical issues. Journal of Infectious Diseases, jiaa457. DOI: 10.1093\/infdis\/jiaa457. (26 August 2020).
    \n    https:\/\/academic.oup.com\/jid\/advance-article\/doi\/10.1093\/infdis\/jiaa457\/5897421<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Simon\u00a0Collins,\u00a0HIV\u00a0i-Base Numerous HIV community groups recently circulated a statement against the use of active challenge studies on COVID-19 vaccine studies. [1] This was in response to a proposal in an open letter from a group of prominent scientists to directly …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[292,278],"tags":[],"class_list":["post-38849","post","type-post","status-publish","format-standard","hentry","category-covid-19-vaccine","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38849","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=38849"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/38849\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=38849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=38849"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=38849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}