{"id":3901,"date":"2000-10-17T07:16:01","date_gmt":"2000-10-17T06:16:01","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3901"},"modified":"2014-07-01T11:41:49","modified_gmt":"2014-07-01T11:41:49","slug":"crystalluria-common-in-hiv-infected-patients-using-indinavir","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3901","title":{"rendered":"Crystalluria common in HIV-positive patients using indinavir"},"content":{"rendered":"<p><strong>An unexpectedly high proportion of HIV-positive\u00a0patients using indinavir develop crystalluria at some point during their first year of treatment, according to researchers in Quebec, Canada. The new study &#8220;establishes the importance of standard urinalysis, including microscopy, in showing the presence of indinavir crystalluria,&#8221; Dr Raymonde F. Gagnon and colleagues from Montreal General Hospital conclude in the September issue of the American Journal of Kidney Diseases.<\/strong><\/p>\n<p>The investigators monitored 54 asymptomatic indinavir-naive HIV-positive\u00a0patients during their first year of indinavir therapy. Patients underwent urinalysis at day 3, week 1, week 2, and then monthly. During the year, 67% of patients tested positive for indinavir crystalluria at least once. After the first 2 weeks, approximately one quarter of the patients tested positive at each time point during the study. These figures may actually be underestimates, Dr Gagnon and colleagues believe, because in a controlled study, patients were probably unusually compliant with recommendations about water intake. Other urinalysis abnormalities were also common. In particular, most urinalysis tests showed low pH and high specific gravity. &#8220;Although the low urine pH may protect against indinavir crystalluria, the high urine specific gravity likely constitutes a major risk factor for the development of crystalluria,&#8221; the authors point out.<\/p>\n<p>Since sufficient hydration could play a large role in preventing indinavir crystalluria and its potential consequences, the Canadian researchers recommend &#8220;that the current management of indinavir-treated individuals should include significantly increased water intake, particularly at the time of and during the first 4 hours after indinavir dosing.&#8221; They also stress the importance of routine urinalysis monitoring in these patients.<\/p>\n<p>Reference:<\/p>\n<p>Am J Kidney Dis. 2000;36:507-515.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>An unexpectedly high proportion of HIV-positive\u00a0patients using indinavir develop crystalluria at some point during their first year of treatment, according to researchers in Quebec, Canada. The new study &#8220;establishes the importance of standard urinalysis, including microscopy, in showing the presence &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-3901","post","type-post","status-publish","format-standard","hentry","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3901","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3901"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3901\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3901"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3901"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}