{"id":3908,"date":"2000-10-17T07:24:21","date_gmt":"2000-10-17T07:24:21","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=3908"},"modified":"2014-07-01T11:41:34","modified_gmt":"2014-07-01T11:41:34","slug":"human-il-12-may-augment-hiv-specific-immunity-in-infected-patients","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/3908","title":{"rendered":"Human IL-12 may augment HIV-specific immunity in HIV-positive patients"},"content":{"rendered":"<p><strong>Promising results of a phase I study suggest that single-dose recombinant human interleukin 12 (rhIL-12) may have therapeutic benefits in HIV-positive\u00a0patients. Dr Mark A. Jacobson of the University of California at San Francisco and multicenter colleagues examined the effects of a single subcutaneous dose of rhIL-12 in a dose-escalation study. They randomized 47 patients with CD4+ T lymphocyte counts between 100 and 500 cells\/\u00b5L to doses ranging from 3 ng\/mg to 1000 ng\/mg or to placebo.<\/strong><\/p>\n<p>At doses greater than 30 ng\/mg, patients demonstrated increases in absolute numbers of CD8+ T lymphocyte cells and natural killer (NK) cells, suggesting an augmentation of HIV-specific immunity. Treatment with rhIL-12 also induced a rise in serum interferon-gamma levels, consistent with earlier studies of the cytokine in both animals and humans. &#8220;Of interest, rhIL-12 administration to HIV-positive\u00a0patients did not change their absolute CD4+ T cell counts or the amount of circulating plasma HIV RNA,&#8221; Dr Jacobson&#8217;s group writes in the October issue of the Journal of Infectious Diseases. This suggests that a single dose of this agent has no &#8220;clinically significant impact either on HIV-induced CD4+ T cell lymphopenia or (via immunomodulation) on HIV replication.&#8221; This finding conflicts with earlier reports, the authors note, and may be a result of trial limitations.<\/p>\n<p>Generally mild and transient adverse effects were associated with rhIL-12 doses lower than 300 ng\/kg, while severe adverse events occurred at higher doses, particularly the 1000 ng\/kg dose. &#8220;The immunomodulatory effects of rhIL-12 might be beneficial in HIV disease,&#8221; the investigators conclude. Further studies on the effects of rhIL-12 in HIV-positive\u00a0patients are currently in progress.<\/p>\n<p>Reference:<\/p>\n<p>J Infect Dis. 2000;182:1070-1076.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Promising results of a phase I study suggest that single-dose recombinant human interleukin 12 (rhIL-12) may have therapeutic benefits in HIV-positive\u00a0patients. Dr Mark A. Jacobson of the University of California at San Francisco and multicenter colleagues examined the effects of &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[41],"tags":[],"class_list":["post-3908","post","type-post","status-publish","format-standard","hentry","category-treatment-strategies"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3908","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=3908"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/3908\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=3908"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=3908"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=3908"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}