{"id":39128,"date":"2020-10-14T07:31:40","date_gmt":"2020-10-14T07:31:40","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=39128"},"modified":"2020-10-18T13:56:38","modified_gmt":"2020-10-18T13:56:38","slug":"outcomes-of-covid-19-in-french-cohort-of-54-hiv-positive-people-on-art","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/39128","title":{"rendered":"Outcomes from COVID-19 in French cohort of 54 HIV positive people on ART"},"content":{"rendered":"

Simon\u00a0Collins,\u00a0HIV\u00a0i-Base<\/b><\/p>\n

A research letter published in the 1 October 2020 edition of AIDS reported results from a prospective observational study in Paris in HIV positive people who were on ART with generally good CD4 counts. [1]<\/strong><\/p>\n

The study included 54 HIV positive adults (60% men) diagnosed with COVID-19 from 1 March to 30 April 2020.<\/p>\n

Median age was 54 years (IQR: 47 to 60) and median CD4 counts was 583 \u200acells\/mm3<\/sup> (IQR: 474 to 773). All were on ART and nearly all (51\/53) had viral load <40\u200a copies\/mL.\u00a0<\/span><\/p>\n

Over median of 29 days (IQR: 29 to 45 days), all for at least 14 days, 35\/54 (65%) developed moderate disease, 14\/54 severe (26%) and 5\/54 were critical (9%). One person died.<\/p>\n

Participants from Sub Saharan Africa were disproportionally affected compared to the clinic population overall (45% vs 30%), with higher rates of severe disease (13\/19 vs 13\/35).<\/p>\n

By multivariate analysis, age , male gender, ethnic origin from Sub Saharan Africa, and metabolic disorder, were associated with severe or critical forms of COVID-19.\u00a0<\/span><\/p>\n

Prior CD4 T cell counts did not differ between groups.<\/p>\n

comment<\/b><\/h3>\n

The disproportionate impact of ethnicity on COVID-19 infection and outcomes is increasingly reported, including in the US and UK. [2, 3]<\/b><\/p>\n

Reference<\/p>\n

    \n
  1. Etienne N et al. HIV infection and COVID-19 risk factors for severe disease. Research letter. AIDS: 2020; 34(12):1771-1774. DOI: 10.1097\/QAD.0000000000002651. (1 October 2020).
    \nhttps:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7493770<\/a><\/li>\n
  2. Meyerowitz EA et al. Disproportionate burden of COVID-19 among racial minorities and those in congregate settings among a large cohort of people with HIV. AIDS. 2020 Oct 1; 34(12): 1781\u20131787.
    \n    https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC7499878<\/a><\/li>\n
  3. Coronavirus (COVID-19) related deaths by ethnic group, England and Wales – Office for National Statistics.
    \n    https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/birthsdeathsandmarriages\/deaths\/articles<\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Simon\u00a0Collins,\u00a0HIV\u00a0i-Base A research letter published in the 1 October 2020 edition of AIDS reported results from a prospective observational study in Paris in HIV positive people who were on ART with generally good CD4 counts. [1] The study included 54 …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[282,278],"tags":[],"class_list":["post-39128","post","type-post","status-publish","format-standard","hentry","category-covid-19-hiv-and-covid-19-coinfection","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39128","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=39128"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39128\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=39128"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=39128"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=39128"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}