{"id":39272,"date":"2020-11-11T07:29:00","date_gmt":"2020-11-11T07:29:00","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=39272"},"modified":"2021-02-08T23:57:04","modified_gmt":"2021-02-08T23:57:04","slug":"hiv-positive-people-in-uk-at-higher-risk-of-worse-outcomes-from-covid-19","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/39272","title":{"rendered":"HIV positive people at higher risk of worse outcomes from COVID-19 in UK study"},"content":{"rendered":"
<\/span>Simon Collins, HIV i-Base<\/strong><\/div>\n
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Results from a prospective observational database study report that being HIV positive is associated with higher risks of 28-day mortality. [1]<\/span><\/strong><\/p>\n<\/div>\n

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The study as published on 23 October in Clinical Infectious Diseases and included results from more than 47,500 people hospitalised with COVID-19, of which 122 (0.26%) had a recorded HIV diagnosis. <\/span><\/p>\n<\/div>\n

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In unadjusted analyses, cumulative risk of mortality was similar in the HIV positive vs HIV negative groups (26.7% vs. 32.1% respectively; p=0.16).<\/p>\n<\/div>\n

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However, the HIV positive group was significantly younger (median 56 versus 74 years; p<0.001) and had more comorbidities.<\/p>\n<\/div>\n

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After adjustment for these and other factors, mortality was higher among people with HIV (aHR: 1.47; 95% CI: 1.01 to 2.14; p=0.05). This association became stronger after adjusting for the other factors (aHR 1.69; 95% CI 1.15 to 2.48; p=0.008) and when restricting the analysis to people aged <60 years (aHR 2.87; 95% CI 1.70-4.84; p<0.001).<\/p>\n<\/div>\n

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comment<\/span><\/h3>\n<\/div>\n
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This study was previously reported in HTB ahead of peer review. [2]<\/span><\/strong><\/p>\n<\/div>\n

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It is important to show the importance of adjusting for the significant differences in HIV positive and negative cases.<\/span><\/strong><\/p>\n<\/div>\n

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This in turn should caution advice for HIV positive people to not rely on a lower age as protection against COVID-19 and also perhaps for HIV positive people older than 60 to be even more careful to follow prevention advice to avoid catching COVID-19.<\/span><\/strong><\/p>\n<\/div>\n

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References<\/span><\/p>\n<\/div>\n

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  1. Geretti AM et al. Outcomes of COVID-19 related hospitalization among people with HIV in the ISARIC WHO clinical characterization protocol (UK): a prospective observational study. Clinical Infectious Diseases, ciaa1605, DOI: 10.1093\/cid\/ciaa1605. (23 October 2020).
    \n<\/span>https:\/\/academic.oup.com\/cid\/advance-article\/doi\/10.1093\/cid\/ciaa1605\/5937133<\/a><\/li>\n
  2. Collins S. HIV associated with worse outcomes from COVID-19 in UK ISARIC and OpenSAFELY databases. HTB (28 August 2020).
    \n    https:\/\/i-base.info\/htb\/38726<\/a><\/li>\n<\/ol>\n

    This report was first posted on 28 October 2020.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

    Simon Collins, HIV i-Base Results from a prospective observational database study report that being HIV positive is associated with higher risks of 28-day mortality. [1] The study as published on 23 October in Clinical Infectious Diseases and included results from …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[282,278],"tags":[],"class_list":["post-39272","post","type-post","status-publish","format-standard","hentry","category-covid-19-hiv-and-covid-19-coinfection","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39272","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=39272"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39272\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=39272"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=39272"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=39272"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}