{"id":39350,"date":"2020-11-11T07:43:59","date_gmt":"2020-11-11T07:43:59","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=39350"},"modified":"2020-11-13T12:15:56","modified_gmt":"2020-11-13T12:15:56","slug":"adverse-pregnancy-outcomes-among-spanish-women-hospitalised-with-covid-19","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/39350","title":{"rendered":"Adverse pregnancy outcomes among Spanish women hospitalised with COVID-19"},"content":{"rendered":"
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\"\"Polly Clayden, HIV i-Base<\/strong><\/p>\n<\/div>\n

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High proportion of Caesarean sections and preterm delivery among pregnant women with COVID-19 in a Spanish cohort \u2013 according to data presented at HIV Glasgow 2020.<\/span><\/b><\/p>\n<\/div>\n

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There was no vertical transmission in this study but one reported case of horizontal transmission through family contact.<\/span><\/b><\/p>\n<\/div>\n

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This main objective of this analysis was to describe clinical and epidemiological characteristics of a cohort of women with SARS<\/span>\u2010<\/span>CoV<\/span>\u2010<\/span>2 during pregnancy and their neonates. It was a prospective, multicentre, observational study of five hospitals in the GESNEO<\/span>\u2010<\/span>COVID cohort. <\/span><\/p>\n<\/div>\n

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The study enrolled women with confirmed SARS<\/span>\u2010<\/span>CoV<\/span>\u2010<\/span>2 by PCR and\/or serology during pregnancy, diagnosed and delivering between 15 March and 31 July 2020 \u2013 there were 105 women included. <\/span><\/p>\n<\/div>\n

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The median age of pregnant women was 34.1 (IQR 28.8 to 37.1) years. The majority (93.3%) were diagnosed in the third trimester and remainder (6.7%) during the second trimester. Over half (64.8%) had symptoms, 30.8% of pneumonia. Almost half of the cohort (43.8%) received treatment for COVID<\/span>\u2010<\/span>19 and 4.8% were admitted to ICU, for a median of 10 days (IQR 6.5 to 18.5). <\/span><\/p>\n<\/div>\n

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Overall, 36.2% of pregnant women had a Caesarean delivery. Severe COVID<\/span>\u2010<\/span>19 was indicated for almost 30% of them.<\/span><\/p>\n<\/div>\n

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There were two sets of twins so 107 neonates were included in the analysis.<\/span><\/p>\n<\/div>\n

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The rate of preterm delivery was 20.2% and small for gestational age was 5.6%. The proportion neonates needing intensive care was 16.8%, for a median duration of 3 days (IQR 1 to 8) \u2013 mostly due to complications with prematurity. And 66.4% of neonates were breastfed.<\/span><\/p>\n<\/div>\n

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One extremely preterm neonate died at 20 days of life due to prematurity-related complications. Another full-term infant died due to unexpected sudden death during early skin-to-skin contact after delivery. Both were born to women with severe pneumonia, admitted to ICU.<\/span><\/p>\n<\/div>\n

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Nasopharyngeal PCR was performed at birth and 100% of neonates tested were negative. One neonate then tested positive at 15\u00a0days of life. The mother was in the ICU with pneumonia \u2013 this was considered to be intra-family transmission. No vertical transmission was reported. <\/span><\/p>\n<\/div>\n

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In multivariate analysis pneumonia was associated with higher risk of Caesarean section: OR 4.2 (95% CI 1.47 to 11.99).<\/span><\/p>\n<\/div>\n

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Pneumonia and positive PCR at delivery were associated with preterm delivery: OR 6.73 (95% CI 2.30 to 21.31) and OR 6.44 (95% CI 1.82 to 31.38), respectively. <\/span><\/p>\n<\/div>\n

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Reference<\/span><\/p>\n<\/div>\n

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Carrasco I et al. SARS-CoV-2 infection in pregnancy and newborn in a Spanish multicentric<\/span>cohort (GESNEO-COVID). <\/span>\u00a0HIV Glasgow \u2013 virtual. 5\u20138 October 2020. Oral abstract 0444.
\n<\/span>https:\/\/vimeo.com\/466268384\/be0793cb39 <\/a>(webcast: 40.45)<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Polly Clayden, HIV i-Base High proportion of Caesarean sections and preterm delivery among pregnant women with COVID-19 in a Spanish cohort \u2013 according to data presented at HIV Glasgow 2020. There was no vertical transmission in this study but one …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,35,289,278],"tags":[299],"class_list":["post-39350","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-pmtct-and-maternal-health","category-covid-19-transmission","category-covid-19","tag-glasgow-2020"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=39350"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39350\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=39350"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=39350"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=39350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}