{"id":39630,"date":"2021-01-22T07:14:00","date_gmt":"2021-01-22T07:14:00","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=39630"},"modified":"2021-01-27T14:36:29","modified_gmt":"2021-01-27T14:36:29","slug":"us-guidelines-for-mrna-vaccines-against-covid-19","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/39630","title":{"rendered":"US guidelines for using mRNA vaccines against COVID-19"},"content":{"rendered":"<div><\/div>\n<div>\n<p class=\"HTBsubhead3authorcredit\"><strong><span lang=\"EN-US\"><b><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/><\/b>Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBsubhead3authorcredit\"><strong><span lang=\"EN-US\">On 30 December 2020, the US guidelines on vaccines against COVID-19 were updated.<\/span><\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYFIRST\"><span lang=\"EN-US\">As with other guidelines on COVID-19, they are likely to be updated frequently.<\/span><\/p>\n<h2 class=\"HTBBODYFIRST\">Main summary<\/h2>\n<\/div>\n<div>\n<ul>\n<li><span lang=\"EN-US\">The current guidelines only cover the two mRNA vaccines approved in the US (Pfizer and Moderna).<\/span><\/li>\n<li>Both vaccines require two doses &#8211; 21 and 28 days apart for the Pfizer and Moderna vaccines, respectively.<\/li>\n<li>Caution is given it the second dose is given within a shorter window.<\/li>\n<li>Neither vaccines has a maximum time within which the second dose should be given.<\/li>\n<li>Although there is no preference between these two vaccines, both doses should be with the same vaccine. There is no data with mixed dosing.<\/li>\n<li>Any other vaccines should be ideally separated by a two-week window,<\/li>\n<li>Further boosting doses are not recommended until further data become available.<\/li>\n<li>Vaccines can be used by people with previous COVID-19.<\/li>\n<li>To include patient counselling on efficacy and safety.<\/li>\n<\/ul>\n<h2>Deferring vaccination<\/h2>\n<\/div>\n<div>\n<ul>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">People who received monoclonal antibodies against COVID-19 or convalescent plasma are recommended to wait 90 days before using a vaccine.<\/span><\/li>\n<li class=\"HTBBODYindent\">People with current symptoms or a recent confirmed exposure should wait until quarantine restrictions are ended before having a vaccine.<\/li>\n<\/ul>\n<h2>Contraindications<\/h2>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">The only people who are not recommended to use these vaccines <\/span><\/p>\n<\/div>\n<div>\n<ul>\n<li class=\"HTBBODYindent\"><span lang=\"EN-US\">Severe allergy after previous mRNA COVID 19 vaccine or any of its components (listed in an appendix).<\/span><\/li>\n<li class=\"HTBBODYindent\">Any previous allergic reaction to polyethylene glycol\u00a0 or polysorbate.<\/li>\n<li class=\"HTBBODYindent\">A history of severe allergy reactions to other vaccines, medicines and foods is not a contraindication to COVID-19 vaccines.<\/li>\n<li class=\"HTBBODYindent\">No underlying health conditions are a contraindication against the COVID-19 vaccines.<\/li>\n<\/ul>\n<h2>Appendices<\/h2>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Several appendices are included on triage for vaccinations, ingredients in each vaccine and characterising allergic reactions.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Reference<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">US CDC. Interim clinical considerations for use of mRNA COVID-19 vaccines currently authorized in the United States. (30 December 2020).<br \/>\n<\/span><a href=\"https:\/\/www.cdc.gov\/vaccines\/covid-19\/info-by-product\/clinical-considerations.html\">https:\/\/www.cdc.gov\/vaccines\/covid-19\/info-by-product\/clinical-considerations.html<\/a><\/p>\n<p><em>This report was first posted on 5 January 2021.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base On 30 December 2020, the US guidelines on vaccines against COVID-19 were updated. As with other guidelines on COVID-19, they are likely to be updated frequently. Main summary The current guidelines only cover the two mRNA &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[285,22],"tags":[],"class_list":["post-39630","post","type-post","status-publish","format-standard","hentry","category-covid-19-guidelines","category-future-meetings"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39630","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=39630"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39630\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=39630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=39630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=39630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}