{"id":39779,"date":"2021-01-22T07:10:01","date_gmt":"2021-01-22T07:10:01","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=39779"},"modified":"2021-02-19T16:51:05","modified_gmt":"2021-02-19T16:51:05","slug":"most-people-hospitialised-with-covid-19-have-at-least-one-symptoms-after-6-months-wuhan-cohort","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/39779","title":{"rendered":"Most people hospitialised with COVID-19 have at least one symptom after 6 months: Wuhan cohort"},"content":{"rendered":"

<\/span><\/strong>Simon\u00a0Collins,\u00a0HIV\u00a0i-Base<\/b><\/p>\n

A study by Huang and colleagues and published in the Lancet provides important results on longer-term outcomes from COVID-19 and importantly highlights the longer recovery times that are now starting to get more attention. [1]<\/strong><\/p>\n

This study includes results from 1,733 adults (from a total of nearly 2500) who were discharged from Jin Yin-tan Hospital in Wuhan, China, between 7 January and 29 May 2020.\u00a0<\/span><\/p>\n

Median age was 57 years (IQR: to ). Follow-up visits were done from 16 June to 3 September 2020, and the median follow-up time was 186 days (IQR: to ). This included subset of 390 with results from lung functions tests and 94 with antibody serology.<\/p>\n

At follow-up, 76% of patients (1,265\/1,655) reported at least one ongoing symptom. The most common were fatigue or muscle weakness (63%, 1,038\/1,655), sleep difficulties (26%, 437\/1,655) and anxiety or depression (23%, 367\/1,733).<\/p>\n

Antibody responses were significantly lower over time in the subset of participants with these results, with 96% vs 58 testing seropositive in acute vs follow-up samples and with median titres of 19 vs 10, respectively.<\/p>\n

Reduced kidney was reported by 13% (107\/822) of participants with previous normal kidney function based on eGFR levels being above vs below 90 mL per 1.73 m2<\/sup>.<\/p>\n

In 349 participants who completed the lung function test, those with more severe illness commonly had reduced lung function. There also reported slightly worse outcomes in a six-minute walking test: 29% at severity scale 5\u20136 walked less than the lower limit of the normal range (compared with 24% at scale 3, and 22% for scale 4).<\/p>\n

However, only 4% of participants had been admitted to ICU during their hospitalisation, therefore underreporting the long-term outcomes from the most severe infections.<\/p>\n

Reference<\/p>\n

Huang C et al. Six-month consequences of COVID-19 in patients discharged from hospital: a cohort study. The Lancet, DOI:10.1016\/ S0140-6736(20)32656-8. (8 January 2021).
\nhttp:\/\/www.thelancet.com\/journals\/lancet\/article\/PIIS0140-6736(20)32656-8\/fulltext<\/a> (website)
\nhttp:\/\/www.thelancet-press.com\/embargo\/longcovid.pdf<\/a> (PDF)<\/p>\n","protected":false},"excerpt":{"rendered":"

Simon\u00a0Collins,\u00a0HIV\u00a0i-Base A study by Huang and colleagues and published in the Lancet provides important results on longer-term outcomes from COVID-19 and importantly highlights the longer recovery times that are now starting to get more attention. [1] This study includes results …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[290,278],"tags":[],"class_list":["post-39779","post","type-post","status-publish","format-standard","hentry","category-covid-19-pathogenesis","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=39779"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/39779\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=39779"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=39779"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=39779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}