{"id":40706,"date":"2021-06-01T07:28:51","date_gmt":"2021-06-01T07:28:51","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=40706"},"modified":"2021-06-01T08:48:04","modified_gmt":"2021-06-01T08:48:04","slug":"us-cdc-reports-10000-breakthrough-infections-after-full-vaccination-showing-success-of-vaccine-programme","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/40706","title":{"rendered":"US CDC reports 10,000 breakthrough infections after full vaccination: showing success of vaccine programme"},"content":{"rendered":"
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Simon Collins, HIV i-Base <\/span><\/strong><\/p>\n<\/div>\n

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On 25 May 2021, the latest issue of MMWR included a review of breakthrough cases of COVID-19 reported up to the ends of April.\u00a0<\/span><\/strong><\/p>\n<\/div>\n

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The 10,262 cases are a tiny percentage (0.01%) of the more than 100 million people fully vaccinated at the time of the analysis, and were expected given that vaccines are not 100% effective. They were largely mild infections, but not always, and perhaps half were linked to new variants.<\/span><\/p>\n<\/div>\n

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The 10,262 cases are a tiny percentage (0.01%) of the more than 100 million people fully vaccinated at the time of the analysis, and were expected given that vaccines are not 100% effective. They were largely mild infections, but not always, and perhaps half were linked to new variants.<\/span><\/p>\n<\/div>\n<\/div>\n

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Breakthrough infections were defined as occurring more than 14 days after receiving the second dose of an authorised vaccine, confirmed by RNA testing. <\/span><\/p>\n<\/div>\n

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Median age was 58 (IQR: 40 to 74) and 63% were women. Approximately 27% were asymptomatic. 995 were hospitalised (not always related to COVID-19). Although 160 people died, this is dramatically lower than without vaccination where the US has reported more than 30 million cases and 600,000 deaths.<\/span><\/p>\n<\/div>\n

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The median age of people who died was 82 (IQR: 71 to 89), including 28 (18%) unrelated to COVID-19.<\/span><\/p>\n<\/div>\n

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Genomic sequencing was only available for 555 (5%) of cases, of which almost two-thirds (n=356, 64%) were variants of concern, including B.1.1.7 (199; 56%), B.1.429 (88; 25%), B.1.427 (28; 8%), P.1 (28; 8%), and B.1.351 (13; 4%).<\/span><\/p>\n<\/div>\n

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The surveillance programme depends on passive reporting so the results are likely an underestimate. Future reports will also only focus on people who are hospitalised.<\/span><\/p>\n

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More than 130 million adults in the US (~40% of adults) have now had two doses.<\/span><\/p>\n<\/div>\n<\/div>\n

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Reference<\/p>\n<\/div>\n

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CDC. COVID-19 vaccine breakthrough infections reported to CDC \u2014 United States, January 1\u2013April 30, 2021. MMWR Morb Mortal Wkly Rep. ePub. 2021 (70). DOI:\u00a010.15585\/mmwr.mm7021e3. (25 May 2021).
\n<\/span>https:\/\/www.cdc.gov\/mmwr\/volumes\/70\/wr\/mm7021e3.htm<\/span><\/a>
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This report was first posted on 26 May 2021.<\/em><\/p>\n<\/div>\n

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\u00a0<\/span><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base On 25 May 2021, the latest issue of MMWR included a review of breakthrough cases of COVID-19 reported up to the ends of April.\u00a0 The 10,262 cases are a tiny percentage (0.01%) of the more than …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[292,278],"tags":[],"class_list":["post-40706","post","type-post","status-publish","format-standard","hentry","category-covid-19-vaccine","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/40706","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=40706"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/40706\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=40706"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=40706"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=40706"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}