{"id":41016,"date":"2021-08-01T06:14:46","date_gmt":"2021-08-01T06:14:46","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=41016"},"modified":"2021-08-01T10:23:21","modified_gmt":"2021-08-01T10:23:21","slug":"rct-shows-no-impact-of-azithromycin-in-reducing-symptoms-of-mild-covid-19-2","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/41016","title":{"rendered":"RCT shows no impact of azithromycin in reducing symptoms of mild COVID-19"},"content":{"rendered":"<div>\n<p class=\"HTBsubhead2articletitle\"><strong><span lang=\"EN-US\"><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/><\/span>Simon Collins, HIV i-Base<\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><strong>The lack of impact from a single dose antibiotic at improving COVID symptoms is likely to surprise few people, but the results from the RCT are published in JAMA.<\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\">Between March 2020 to May 2021, this US out-patient study <span lang=\"EN-US\">randomized 263 outpatients (2:1) to a single oral 1.2 g dose of azithromycin (n\u2009=\u2009171) or matching placebo (n\u2009=\u200992).<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Among outpatients with SARS-CoV-2 infection, treatment with a single dose of oral azithromycin compared with placebo did not result in a greater likelihood of being free of symptoms at day 14.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">And by day 21, <\/span>more participants in the azithromycin group had been hospitalised compared with the placebo group: 5 vs 0 (difference +4%; 95% CI: \u22121% to 9%;\u00a0\u2009p=0.16), <span lang=\"EN-US\">although the difference was not significant.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBreference-noindent\"><span lang=\"EN-US\">Reference<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBreference-noindent\">Oldenburg CE et al. Effect of oral azithromycin vs placebo on COVID-19 symptoms in outpatients with SARS-CoV-2 infection: A randomized clinical trial. JAMA. <span lang=\"EN-US\">doi:10.1001\/jama.2021.11517<\/span><span lang=\"EN-US\">. (16 July 2021).<br \/>\n<\/span><a href=\"https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2782166\">https:\/\/jamanetwork.com\/journals\/jama\/fullarticle\/2782166<\/a><\/p>\n<p><em>This post was first published on 17 July 2021.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base The lack of impact from a single dose antibiotic at improving COVID symptoms is likely to surprise few people, but the results from the RCT are published in JAMA. Between March 2020 to May 2021, this &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[283,278],"tags":[],"class_list":["post-41016","post","type-post","status-publish","format-standard","hentry","category-covid-19-investigational-drugs","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/41016","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=41016"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/41016\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=41016"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=41016"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=41016"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}