{"id":41022,"date":"2021-08-01T06:32:25","date_gmt":"2021-08-01T06:32:25","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=41022"},"modified":"2021-08-01T10:17:49","modified_gmt":"2021-08-01T10:17:49","slug":"antibody-responses-to-pfizer-vaccine-in-hiv-positive-people-with-high-cd4-counts","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/41022","title":{"rendered":"Antibody responses to Pfizer vaccine in HIV positive people with high CD4 counts"},"content":{"rendered":"
\n

<\/span>Simon Collins, HIV i-Base<\/strong><\/p>\n<\/div>\n

\n

A small cohort of 12 HIV positive people had similar immune responses to the Pfizer BNT162b2 vaccine as 17 HIV negative people. <\/span><\/strong><\/p>\n<\/div>\n

\n

The study included 12 HIV positive people (7 women, 5 men) and 17 HIV negative controls (7 women, 10 men) with blood samples taken 7 to 17 days after the second vaccine dose.<\/span><\/p>\n<\/div>\n

\n

Baseline characteristics of the HIV group included median CD4 count or 913 cells\/mm3<\/sup> (range: 649 to 1678) with undetectable viral load <50 copies\/mL (n=9) or very low level viraemia <100 copies\/mL (n=3).<\/span><\/p>\n<\/div>\n

\n

There was no significant difference between antibody titers in the positive vs negative groups (median 8.84 vs 9.49 respectively, p=0.07. There were also no differences between the groups for responses to any common variants or in the breadth of T-cell responses.<\/span><\/p>\n<\/div>\n

\n

comment<\/span><\/h3>\n<\/div>\n
\n

These data are useful but ideally should have been published earlier \u2013 and the phase 3 studies should also have also enrolled larger groups of HIV positive people and others at higher risk.<\/span><\/strong><\/p>\n<\/div>\n

\n

The HIV positive group all had very high CD4 counts on ART when so-called \u201cnormal\u201d responses would be expected.<\/span><\/strong><\/p>\n<\/div>\n

\n

It is important for all vaccines to report responses that include a wider range of low CD4 counts and higher levels of viral load.<\/span><\/strong><\/p>\n<\/div>\n

\n

Reference<\/span><\/p>\n

Woldemeskel<\/span> BA et al. <\/span>The BNT162b2 mRNA <\/span>vaccine elicits robust humoral and cellular immune responses in people living with<\/span> HIV<\/span>.<\/span> ciab648,\u00a0<\/span>doi: 10.1093\/cid\/ciab648. (<\/span>22 July 2021<\/span>).
\n<\/span>https:\/\/academic.oup.com\/cid\/advance-article\/doi\/10.1093\/cid\/ciab648\/6325617<\/a><\/p>\n

This report was first published on 26 July 2021.<\/em><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base A small cohort of 12 HIV positive people had similar immune responses to the Pfizer BNT162b2 vaccine as 17 HIV negative people. The study included 12 HIV positive people (7 women, 5 men) and 17 HIV …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[282,292,278],"tags":[],"class_list":["post-41022","post","type-post","status-publish","format-standard","hentry","category-covid-19-hiv-and-covid-19-coinfection","category-covid-19-vaccine","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/41022","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=41022"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/41022\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=41022"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=41022"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=41022"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}