{"id":41905,"date":"2021-12-20T07:38:26","date_gmt":"2021-12-20T07:38:26","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=41905"},"modified":"2021-12-21T11:47:05","modified_gmt":"2021-12-21T11:47:05","slug":"rare-cases-of-pml-diagnosed-at-cd4-200-with-undetectable-viral-load","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/41905","title":{"rendered":"Rare cases of PML diagnosed at CD4 >200 with undetectable viral load"},"content":{"rendered":"
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Simon Collins, HIV i-Base<\/strong><\/p>\n<\/div>\n

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Although <\/span>progressive multifocal leukoencephalopathy\u00a0(PML) is now uncommon, a review published in AIDS reports rare cases from a large French of PML at higher CD4 counts and with undetectable viral load.<\/strong><\/p>\n<\/div>\n

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From 571 cases of PML reported in the Dat\u2019AIDS cohort between 2000 and 2019, 10 cases (1.75%) occurred at a CD4 cell count >200 cells\/mm3<\/sup>\u00a0and an undetectable HIV RNA viral load after at least 6 months of ART.<\/p>\n<\/div>\n

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Median CD4 cell count at PML diagnosis was 395 cells\/mm3<\/sup>\u00a0[IQR: 310 to 477]. The median time of undetectable HIV viral load was 41 months (IQR: 8 to 67).<\/p>\n<\/div>\n

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Other details include that: \u201conly one person treated with rituximab-based chemotherapy for a large B-cell lymphoma had an established risk factor for PML. Among the nine others, multiple factors of impaired immunity could have led to PML: HCV co-infection (n=6), cirrhosis (n=4), HHV-8 co-infection (n=3) with Kaposi’s sarcoma (n=2) in association with Castleman’s disease (n=1) and indolent IgA multiple myeloma (n=1).<\/p>\n<\/div>\n

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Reference<\/span><\/p>\n<\/div>\n

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Dalla-Pozza P et al. Progressive multifocal leukoencephalopathy\u00a0in patients with immuno-virological control and at least 6 months of combination antiretroviral therapy. AIDS, doi: 10.1097\/QAD.0000000000003145. (6 December 2021).
\n<\/span>https:\/\/journals.lww.com\/aidsonline\/Abstract\/9000\/Progressive_multifocal_leukoencephalopathy_in.96259.aspx<\/a><\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base Although progressive multifocal leukoencephalopathy\u00a0(PML) is now uncommon, a review published in AIDS reports rare cases from a large French of PML at higher CD4 counts and with undetectable viral load. From 571 cases of PML reported …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[31],"tags":[],"class_list":["post-41905","post","type-post","status-publish","format-standard","hentry","category-opportunistic-infections-coinfections-and-complications"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/41905","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=41905"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/41905\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=41905"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=41905"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=41905"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}