{"id":4196,"date":"2001-03-17T15:16:38","date_gmt":"2001-03-17T15:16:38","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=4196"},"modified":"2014-06-12T14:34:51","modified_gmt":"2014-06-12T14:34:51","slug":"plasma-cysteine-deficiency-and-decreased-reduction-of-nitrososulfa-methoxazole-with-hiv-infection","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4196","title":{"rendered":"Plasma cysteine deficiency and decreased reduction of nitrososulfa-methoxazole with HIV Infection"},"content":{"rendered":"<p><strong>The aim of these studies was to determine whether HIV-infected patients have a plasma thiol deficiency and whether this is associated with decreased detoxification of the toxic metabolites of sulfamethoxazole. Reduced, oxidized, protein-bound, and total thiol levels were measured in 33 HIV-positive patients and 33 control subjects by an HPLC method utilizing the fluorescent probe bromobimane.<\/strong><\/p>\n<p>The reduction of sulfamethoxazole hydroxylamine and nitrososulfamethoxazole by plasma and the plasma redox balance in the presence of nitrososulphamethoxazole were also determined by HPLC. Reduced plasma cysteine was significantly (p &lt; 0.0001) lower in HIV-positive patients (13.0 +\/- 3.0 ?M) when compared with control subjects (16.9 +\/- 3.0 ?M). Although there was no difference in oxidized, protein-bound, and total cysteine, the thiol\/disulfide ratios were lower in HIV-positive patients.<\/p>\n<p>Reduced homocysteine was elevated in patients. Plasma from HIV-positive patients was less able to detoxify nitrososulfamethoxazole than control plasma. These findings show that the disturbance in redox balance in HIV-positive patients may alter metabolic detoxification capacity, and thereby predispose to sulfamethoxazole hypersensitivity.<\/p>\n<p>Reference:<\/p>\n<p>Naisbitt DJ, Vilar FJ, Stalford AC et al. AIDS Res Hum Retroviruses 2000 Dec;16(18):1929-1938.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The aim of these studies was to determine whether HIV-infected patients have a plasma thiol deficiency and whether this is associated with decreased detoxification of the toxic metabolites of sulfamethoxazole. Reduced, oxidized, protein-bound, and total thiol levels were measured in &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[8],"tags":[],"class_list":["post-4196","post","type-post","status-publish","format-standard","hentry","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4196","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4196"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4196\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4196"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4196"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4196"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}