{"id":4211,"date":"2001-03-17T15:35:04","date_gmt":"2001-03-17T14:35:04","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=4211"},"modified":"2014-06-12T14:31:24","modified_gmt":"2014-06-12T14:31:24","slug":"seroconversion-in-kenyan-sex-workers-linked-with-reduced-hiv-specific-immune-response","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4211","title":{"rendered":"Seroconversion in Kenyan sex-workers linked with reduced HIV-specific immune response"},"content":{"rendered":"<p><strong>HIV-specific CD8+ T cells play an important role in controlling viraemia, the authors explain, but maintenance of such a circulating cytotoxic T lymphocyte (CTL) presence may require ongoing antigenic stimulus.<\/strong><\/p>\n<p>Dr Rupert Kaul, and colleagues, from the University of Nairobi in Kenya, examined 11 late seroconverters, who had previously met criteria for HIV-1 resistance, for evidence of HIV-1 &#8211; specific CD8+ responses. Dr Kaul&#8217;s findings follow the preliminary description of 6 highly exposed, previously uninfected sex workers who had seroconverted after they stopped continual exposure to HIV-1. Pre-seroconversion data were available for 6 of the 11 women. Four of the 6 women had HIV-1 &#8211; specific CTL responses ranging from 5 months to 18 months before seroconversion, the authors report.<\/p>\n<p>Seroconversion was not associated with contraceptive method or occurrence of sexually transmitted diseases over the preceding year, the researchers note, but overall reduction in sex work\u00d1taking a break or reducing the number of daily clients\u00d1was significantly associated with late seroconversion. Only 2 of the 11 late seroconverters had not experienced a decrease in sex work. While there was no decrease in the number of daily clients, 1 of the 2 women reported increased condom use in the year preceding seroconversion, followed by decreased condom use at the time of seroconversion.<\/p>\n<p>In 6 of 7 women who took at least a 2-month break from sex work, HIV-1 &#8211; specific responses were no longer seen in peripheral blood mononuclear cells, the report indicates, and 3 of 4 women who retired from sex work experienced a loss of such responses. Three such women who returned to sex work redeveloped HIV-1 &#8211; specific responses after a lag of 12.4 months on average, according to the results.<\/p>\n<p>&#8220;The association of HIV-1 seroconversion with reduced sex work seems initially counterintuitive, but it might be compatible with a loss or diminution of HIV-1 &#8211; specific CTL in the absence of ongoing antigenic stimulation,&#8221; the authors conclude.<\/p>\n<p>Reference:<\/p>\n<p>J Clin Invest. 2001;107:273-275,341-349.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HIV-specific CD8+ T cells play an important role in controlling viraemia, the authors explain, but maintenance of such a circulating cytotoxic T lymphocyte (CTL) presence may require ongoing antigenic stimulus. Dr Rupert Kaul, and colleagues, from the University of Nairobi &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[44],"tags":[],"class_list":["post-4211","post","type-post","status-publish","format-standard","hentry","category-womens-health"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4211","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4211"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4211\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4211"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4211"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4211"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}