{"id":4216,"date":"2001-03-17T15:37:33","date_gmt":"2001-03-17T15:37:33","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=4216"},"modified":"2014-06-12T14:27:39","modified_gmt":"2014-06-12T14:27:39","slug":"drugs-need-not-be-stopped-because-of-neutropenia-in-hiv-infected-patients","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4216","title":{"rendered":"Drugs need not be stopped because of neutropenia in HIV-positive patients"},"content":{"rendered":"<p><strong>Neutropenia in the presence of HIV infection is rarely severe and is not usually associated with additional infection, according to data from a prospective study carried out in London. Patients participating in the study continued drug therapy during the episodes of neutropenia, which resolved on mean average within 21 days.<\/strong><\/p>\n<p>Dr David A. J. Moore and colleagues at Chelsea and Westminster Hospital followed all adult HIV-positive\u00a0patients at their clinic who developed absolute neutrophil counts of less than 1000 cells\/mL. They report their findings in the February 1st issue of Clinical Infectious Diseases. From 17 000 inpatient and outpatient visits, 87 patients with new neutropenic episodes were identified. All but 3 patients were being treated with potentially myelosuppressive therapy, most with zidovudine, lamivudine and\/or co-trimoxazole. For those with a first episode, the mean CD4+ cell count was 153\/mL. The mean CD4+ cell count was lower, 103\/mL, for subsequent episodes of neutropenia. First episodes averaged 25 days in duration, compared with 17 days for subsequent episodes. Only 3 patients presented with neutrophil counts less than 200 cells\/mL. Only 4 serious and 8 more moderate infections developed during an episode of neutropenia. Two of the serious infections occurred in subjects with neutrophil count nadirs less than 200 cells\/mL. Patients with infections had a lower mean CD4+ cell count than those without infections, 64\/mL vs 126\/mL.<\/p>\n<p>&#8220;An observational strategy may be the optimal management in the absence of sepsis,&#8221; Dr Moore&#8217;s team concludes.<\/p>\n<p>Reference:<\/p>\n<p>Clin Infect Dis. 2001;32:469-476.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neutropenia in the presence of HIV infection is rarely severe and is not usually associated with additional infection, according to data from a prospective study carried out in London. Patients participating in the study continued drug therapy during the episodes &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,8],"tags":[],"class_list":["post-4216","post","type-post","status-publish","format-standard","hentry","category-antiretrovirals","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4216","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4216"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4216\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4216"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4216"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4216"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}