{"id":42237,"date":"2022-03-01T07:33:57","date_gmt":"2022-03-01T07:33:57","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=42237"},"modified":"2022-09-12T07:49:20","modified_gmt":"2022-09-12T07:49:20","slug":"croi-2022-other-studies-on-anal-cancer","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/42237","title":{"rendered":"CROI 2022: Other studies on anal cancer"},"content":{"rendered":"

\"CROIKirk Taylor, HIV i-Base<\/strong><\/p>\n

In addition to the ANCHOR study reported above [1], CROI 2022 included two other posters that are worth reporting.<\/strong><\/p>\n

Risk factors associated with anal cancer<\/h2>\n

The first was a retrospective chart review of young MSM (n=100) and transgender women (n=3) that attended a youth clinic in Atlanta, GA. [2].<\/p>\n

HIV positive subjects were aged 19 (SD\u00b1 2) at presentation, 91% were Black.<\/p>\n

Anal warts were reported by 83% and 65% had received surgical treatment; 12% of subjects had received full course of HPV vaccination.<\/p>\n

High grade anal intraepithelial neoplasia (AIN) was detected in 63% of participants.<\/p>\n

Adjusted odds ratios indicated that incomplete HPV vaccination (5.34; 90% CI: 1.30 to 21.93; p=0.05) and previous surgical treatment (2.59; 90% CI: 1.18 to 5.66; p=0.05) were associated with increased chance of anal cancer.<\/p>\n

Although this study identifies potential risk factors for anal cancers, it is limited to a single youth clinic in Atlanta and the low number of trans women included (n=3) limit the conclusions that can be drawn for this population.<\/p>\n

HPV risk correlates with anal cancer risk<\/h2>\n

A second larger study reported that screening for pre-cancerous anal dysplasia was conducted between 2014 to 2020 in 1397 HIV positive people aged under 35. [3]<\/p>\n

Participants in this group were 93% male and 28% had received HPV vaccination prior to screening.<\/p>\n

Prevalence of high grade anal HSIL was 44% across the cohort. Age at time of diagnosis did not correlate with risk of anal cancer.<\/p>\n

HPV vaccination was associated with lower rates of HPV infection, suggesting a need to increase rates of vaccination in high-risk populations.<\/p>\n

Taken together, these studies indicate the need to increase screening programmes for HSIL to prevent and treat anal cancers in high-risk individuals. Further data is required to stratify relative risk for different populations (e.g. trans women).<\/p>\n

HPV vaccines may provide protection against HSIL and anal cancers in MSM and HIV positive populations.<\/p>\n

References<\/p>\n

    \n
  1. Talyor K. CROI 2022: ANCHOR study reduces anal cancer by 57% and supports screening for people living with HIV. HTB (February 2022).
    \nhttps:\/\/i-base.info\/htb\/42226<\/a><\/li>\n
  2. Loerinc et al. Factors associated with anal dysplasia among young MSM and TW with HIV in Atlanta. CROI 2022. Virtual 12-16 Feb 2022. Poster 562.
    \n    https:\/\/www.croiconference.org\/abstract\/factors-associated-with-anal-dysplasia-among-young-msm-and-tw-with-hiv-in-atlanta\/<\/a><\/li>\n
  3. Sigel et al. Results of anal dysplasia screening in people with HIV younger than 35. CROI 2022. Virtual 12-16 Feb 2022. Poster 561.
    \n    https:\/\/www.croiconference.org\/abstract\/prevalence-and-severity-of-hpv-associated-anal-disease-in-pwh-younger-than-35\/<\/a><\/li>\n<\/ol>\n

    This report was first published on 17 February 2022.<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"

    Kirk Taylor, HIV i-Base In addition to the ANCHOR study reported above [1], CROI 2022 included two other posters that are worth reporting. Risk factors associated with anal cancer The first was a retrospective chart review of young MSM (n=100) …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,18],"tags":[318],"class_list":["post-42237","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-cancer-and-hiv","tag-croi-2022"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42237","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=42237"}],"version-history":[{"count":2,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42237\/revisions"}],"predecessor-version":[{"id":44080,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42237\/revisions\/44080"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=42237"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=42237"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=42237"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}