{"id":42367,"date":"2022-03-01T07:12:47","date_gmt":"2022-03-01T07:12:47","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=42367"},"modified":"2022-03-01T11:57:09","modified_gmt":"2022-03-01T11:57:09","slug":"melatonin-does-not-protect-against-sars-cov-2","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/42367","title":{"rendered":"Melatonin does not protect against SARS-CoV-2"},"content":{"rendered":"<div>\n<div>\n<p class=\"HTBsubhead2articletitle\"><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><strong><span lang=\"EN-US\"><img loading=\"lazy\" decoding=\"async\" class=\" alignright\" src=\"https:\/\/i-base.info\/wp-content\/uploads\/2020\/03\/COVID-19-graphic.png\" width=\"231\" height=\"142\" \/>Results from a randomised study reported no benefit of daily oral melatonin (2 mg QD) for 12 weeks compared to placebo as prophylaxis against SARS-CoV-2 in 314 Spanish health workers.<\/span><\/strong><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">More infections occurred in the active arm (5.5% vs 2.6%, p=0.2) together with more treatment-related side effects (n=67 vs 43, p=0.04), mainly poor sleep.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Melatonin has anti-viral activity, largely supported by animal studies, but a human study reported potentially negative effects for people living with HIV.<\/span><\/p>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\"> It is important that the thousands of research studies hoping to find benefits in preventing or treating COVID-19 with repurposed drugs publish their results, even when no effect is found.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Participants would have brought their own hopes to these studies.<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Reference<\/span><\/p>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\"><span lang=\"EN-US\">Garcia-Garcia et al. Melatonin in the prophylaxis of SARS-CoV-2 infection in healthcare workers (MeCOVID): A randomised clinical trial. J. Clin. Med. 2022, 11(4), 1139. (21 February 2022).<br \/>\n<\/span><a href=\"https:\/\/doi.org\/10.3390\/jcm11041139\">https:\/\/doi.org\/10.3390\/jcm11041139<\/a><\/p>\n<p><em>This report was first published on 27 February 2022.<\/em><\/p>\n<\/div>\n<\/div>\n<div>\n<p class=\"HTBBODYtext\">\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Results from a randomised study reported no benefit of daily oral melatonin (2 mg QD) for 12 weeks compared to placebo as prophylaxis against SARS-CoV-2 in 314 Spanish health workers. More infections occurred in the active &hellip;<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[289],"tags":[],"class_list":["post-42367","post","type-post","status-publish","format-standard","hentry","category-covid-19-transmission"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42367","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=42367"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42367\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=42367"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=42367"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=42367"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}