{"id":42389,"date":"2022-03-01T07:20:30","date_gmt":"2022-03-01T07:20:30","guid":{"rendered":"https:\/\/i-base.info\/htb\/?p=42389"},"modified":"2022-03-01T11:48:22","modified_gmt":"2022-03-01T11:48:22","slug":"long-covid-may-be-more-common-in-people-living-with-hiv","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/42389","title":{"rendered":"Long COVID may be more common in people living with HIV"},"content":{"rendered":"
<\/div>\n
\n

Simon Collins, HIV i-Base<\/span><\/strong><\/p>\n<\/div>\n

\n

A US paper published ahead of peer-review <\/span>reported broadly similar SARS-CoV-2 specific humoral and cellular immune responses in 39 people living with and 43 closely-matched HIV negative people recovering from COVID-19, but significantly higher rates of long COVID (OR: 4.01, 95% CI: 1.45 to 11.1), p=0.008.<\/strong><\/p>\n<\/div>\n

\n

Participants were enrolled in the Long-term Impact of Infection with Novel Coronavirus (LIINC) COVID-19 recovery cohort at UCSF (NCT 04362150). Long COVID was defined by any symptoms present more than six weeks after diagnosis of COVID-19. Median time to assessment and severity of symptoms were similar between groups.<\/span><\/p>\n<\/div>\n

\n

HIV positive participants were on effective ART with undetectable viral load. Median (IQR) CD4 count and CD4:CD8 ratios were 596 cells\/mm3<\/sup>(IQR: 404 to 740) vs 670 cells\/mm3<\/sup> (IQR: 594 to 918) and 0.94 (IQR: 0.51 to 1.10) vs 2.00 (IQR: 1.52 to 2.32), in the HIV+ vs HIV\u2013 groups, respectively.<\/p>\n<\/div>\n

\n

Higher proportions of PD-1 CD4 T cells and significantly higher levels of some inflammatory markers (IL-6, TNF-alpha, and IP-10) were associated with persistent symptoms.<\/p>\n<\/div>\n

\n

Detailed immunological responses are also reported.<\/p>\n<\/div>\n

\n

comment<\/span><\/h3>\n<\/div>\n
\n

This study reported early four-fold higher risks of long COVID compared to well-matched HIV negative controls.<\/span><\/strong><\/p>\n<\/div>\n

\n

However, the small size makes the study unlikely to be powered to look at the HIV effect and also cautioned that the results need to be supported by larger studies.<\/span><\/strong><\/p>\n<\/div>\n

\n

Reference<\/span><\/p>\n<\/div>\n

\n

Peluso MJ. Post-acute sequelae and adaptive immune responses in people living with HIV recovering from SARS-COV-2 infection. (14 February 2022).
\n<\/span>https:\/\/www.medrxiv.org\/content\/10.1101\/2022.02.10.22270471v1.full<\/a><\/p>\n<\/div>\n

\n

\n<\/p><\/div>\n","protected":false},"excerpt":{"rendered":"

Simon Collins, HIV i-Base A US paper published ahead of peer-review reported broadly similar SARS-CoV-2 specific humoral and cellular immune responses in 39 people living with and 43 closely-matched HIV negative people recovering from COVID-19, but significantly higher rates of …<\/p>\n","protected":false},"author":3,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[282,278],"tags":[],"class_list":["post-42389","post","type-post","status-publish","format-standard","hentry","category-covid-19-hiv-and-covid-19-coinfection","category-covid-19"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=42389"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/42389\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=42389"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=42389"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=42389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}