{"id":4247,"date":"2001-04-17T20:22:23","date_gmt":"2001-04-17T19:22:23","guid":{"rendered":"http:\/\/moomango.co.uk\/htb\/?p=4247"},"modified":"2014-06-12T14:10:15","modified_gmt":"2014-06-12T14:10:15","slug":"haart-improves-subcortical-functioning-in-cognitively-impaired-hiv-patients","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/4247","title":{"rendered":"HAART improves subcortical functioning in cognitively impaired HIV patients"},"content":{"rendered":"<p><strong>Highly active antiretroviral therapy (HAART) improves the mental performance of patients with HIV-related cognitive impairment, but the rate of improvement varies between different cognitive fields.<\/strong><\/p>\n<p>Dr. Sandra Suarez and colleagues from the Groupe hospitalier Pitie-Salpetriere in Paris assessed the impact of HAART on various cognitive functions in 53 cognitively impaired and 38 non-impaired HIV-infected patients. Subjects were given one to six serial neuropsychological tests and followed for a mean of 12.3 months.<\/p>\n<p>Despite a 25% mortality rate, the cognitively impaired group showed improvements in cognitive functioning that correlated with the duration of HAART, according to a report published in the January 26th issue of AIDS. However, while psychomotor test performance improved steadily with HAART, memory test performance seemed to reach a plateau.<\/p>\n<p>&#8220;Psychomotor speed, verbal anterograde memory, and executive functions&#8221; improved with HAART, the authors note. &#8220;These results reinforce our previous finding that memory impairment in immunocompromised HIV-1-infected patients results from subcorticofrontal dysfunction and also explain why the Mini-Mental State Examination score (reflecting cortical dysfunction) is not improved on HAART.&#8221;<\/p>\n<p>The investigators point out that &#8220;additional longitudinal surveys are required to determine the long-term impact of HAART on neuropsychological outcome and the possible influence of this action on patients&#8217; quality of life.&#8221;<\/p>\n<p>Reference:<\/p>\n<p>AIDS 2001;15:195-200.<\/p>\n<p>Source: Reuters Health<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Highly active antiretroviral therapy (HAART) improves the mental performance of patients with HIV-related cognitive impairment, but the rate of improvement varies between different cognitive fields. Dr. Sandra Suarez and colleagues from the Groupe hospitalier Pitie-Salpetriere in Paris assessed the impact &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-4247","post","type-post","status-publish","format-standard","hentry","category-other-news"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4247","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=4247"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/4247\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=4247"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=4247"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=4247"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}